Could Phototherapy Reverse Visual Deficits in Patients with RelapsingRemitting Multiple Sclerosis?
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 5
Abstract
Background: Multiple sclerosis is a neurodegenerative disease of the central nervous system, causing irreversible deficits of the visual pathway with unknown effective treatment. Purpose: to investigate the efficacy of two original phototherapy programs on reversing the damage caused by multiple sclerosis to the neurophysiological functions of Optic nerves. Study Design: Repeated measures randomized control trial. Materials and methods: 24 patients with relapsing-remitting multiple sclerosis, from both sexes completed the study, age 25-45 years; randomly assigned into four groups. 7 patients in the control group (1); received monthly Solu -Medrol. 6 Patients in group (2) received Solu-Medrol plus low intensity laser therapy LILT 850 nm. 6 patients in group (3) received Solu-Medrol plus broad band ultraviolet B radiation BB-UVBR (280-320 nm). 5 patients in group (4) received SoluMedrol, scanner LILT and BB-UVBR; all three groups received sessions 3 days/week for 12 sessions. Visual evoked potentials (VEP) were assessed pre-treatment, post treatment, 3 months follow up. Results: Highly significant improvement (p=.009) of the right Optic nerve was recorded in the BB-UVBR group, and was sustainable at follow up. Lesser improvements were recorded in the (LLLT+UVBR) group, VEP of the right eye showed significant improvement (p=.022). However; no statistically significant improvements were recorded between the four groups post treatment and at follow up (p≥0.05). Conclusion: BB-UVBR therapy solely has the potential to efficiently ameliorate the severity of disability status and reverse Optic neuritis, rather than LILT with a counterproductive role of the combination therapy.
Authors and Affiliations
Shimaa Abdelalim Essa
Keywords
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