COVID-19 Infections and Vitamin D Deficiency in Pregnancy
Journal Title: Journal of Clinical Immunology & Microbiology - Year 2021, Vol 2, Issue 3
Abstract
Corona virus disease COVID-19 has been a global health threat since November 2019. It has been reported as 6th cause of global public health emergency by World Health Organisation on January 2020. Serum cholecalciferol or calcidiol is the prime marker for the vitamin D status of a person. It has also been gaining importance in prevention of COVID-19 disease severity. Vitamin D has proven cellular level modulation in both the adaptive and innate immune system through cytokines and regulation of cell signalling pathways. This vitamin has been observed to be lower than the optimal levels in pregnancy. The foetal demand for the vitamin increases during the early embryogenesis hence it is reported lowest in the first trimester. It has been noted to increase gradually during second trimester and reaches sufficient limits in third trimester. There is a compensation of serum cholecalciferol levels in third trimester due to the placental secreting receptors. This review analyses the immunomodulatory property of serum cholecalciferol and its effect on T regulatory cell count which is the predicting tool for disease severity in COVID-19.
Authors and Affiliations
A Julie Christy*, Saraswathi Perumal, Sumathy Ravi
Keywords
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- EP ID EP699111
- DOI http://dx.doi.org/10.46889/JCIM.2021.2308
- Views 113
- Downloads 0
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