COX and LOX inhibitory potential of Abroma augusta and Desmodium gangeticum
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 3
Abstract
The present study was aimed to evaluate the cyclooxygenase (COX) and lipoxygenase (LOX) inhibitory activity of Abroma augusta (AA) and Desmodium gangeticum (DG). Initially In-vivo anti-inflammatory activity of aqueous extract (AqE) of aerial parts of DG (100 mg/ml) and petroleum ether extract (PEE) of roots of AA (250 mg/ml) was assessed in carrageenan induced paw oedema model in albino wistar rats. In addition, each plant extract was evaluated for COX- 1, COX-2 and LOX inhibitory activity to determine the possible mechanism of their antiinflammatory activity. The results of the study demonstrated that each plant extract significantly (p<0.0001) reduces the paw volume compared with standard drug Ibuprofen (100 mg/kg b.w.). The percentage inhibitory activity of AqE of DG against COX-2 (IC50=39. 5 µg/ml) were generally higher to that of COX-1 (IC50=49. 5 µg/ml), however, at the same concentrations PEE of AA demonstrated inhibitory activity against COX-1 (IC50=36. 5 µg/ml) to a greater extent than COX-2 (IC50=59 µg/ml). Moderate inhibition of LOX activity was demonstrated by DG (IC50=57.0 µg/ml). AA exhibited weak inhibitory action on LOX activity at the same concentrations (IC50=75.5 µg/ml). The results of the study concluded that anti-inflammatory activity of plant extracts could be due to inhibition of COX and LOX enzymes and thus supports the traditional use of the above mentioned plants in inflammatory disorders.
Authors and Affiliations
Rekha Bisht, S. Bhattacharya, Yusuf Ali Jaliwala
Keywords
Related Articles
- EP ID EP49560
- DOI -
- Views 190
- Downloads 1
Anti-hyperglycaemic activity of Pergularia daemia (Forssk.) Chiov
Pergularia daemia (Forssk.) Chiov. is commonly known as ‘Velipparuthi’ and its leaves are traditionally used to treat fevers, rheumatism, liver disorders, emetic and expectorant. The present work is aimed to evaluate t...
Antinociceptive properties of dichloromethane: methanolic leaf and root bark extracts of Carissa edulis in rats
Conventional medications are expensive and arguably associated with various severe adverse effects, hence the need to develop herbal agents that are effective as alternative. Carissa edulis (Forssk.) Vahl is the herb th...
Cytotoxicity assessment of the stem bark of Tieghemella heckelii Pierre ex. A Chev. (Sapotaceae) towards Vero and RD human cancer Cell Lines
The present study aimed at investigating the cytotoxicity of the stem bark of Tieghemella heckelii Pierre ex. A Chev (Sapotaceae). For this purpose, plant extracts were put into contact separately with the different Ver...
Pharmacognostical and Pharmaceutical evaluation of Herbo mineral Formulation: Aragvadhadi taila
Background: Aragvadhadi taila is a Sneha Kalpana, indicated in Kushtha Roga specially in Shvitra (Vitiligo) Roga. In present study, it has been used for external application in Shvitra (Vitiligo) Roga. Objective: Prese...
Gastro-duodenal protective effect of aqueous leaf extract of Daucuscarota sativus Linn. (Apiaceae) in rats and its possible mechanism of action
Background: Daucuscarota sativus L. (Apiaceae) commonly known as ‘carrot’ is a multipurpose herb cultivated in different parts of the world for its edible roots, juice, oils and leaves. Carrot root as well as its leave...