CRIMEAN CONGO HEMORRHAGIC FEVER - AN ARTICLE REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
Crimean–Congo hemorrhagic fever (CCHF) caused by negative-sense, single-stranded RNA virus in the genus Nairovirus, family Bunyaviridae. (CCHF) is a tick-borne infectious disease characterized by fever, malaise, headache, nausea, vomiting, diarrhoea, sore throat, muscle aches, hemorrhage and thrombocytopenia. CCHF has the most extensive geographic range of the medically significant tick-borne viruses occurring in Africa, Europe and Asia & found recently in India (Ahmadabad) in 2011,become a serious threat to public health. CCHF was first diagnosed and conformed by IgM serology or RT-PCR in Turkey in 2002. Intravenous or oral ribavirin has been used in several countries to treat the disease for more than 20 years.Virus-associated hemophagocytic syndrome has been found to contribute to the exacerbation of CCHF in some patients, and the administration of methylprednisolone at high doses was observationally undertaken in patients with CCHF and virus-associated hemophagocytic syndrome, with promising results. The intention of this review is to summarize the current status of CCHF with effective therapeutics and preventive measures.
Authors and Affiliations
Najam Khan , Anushree Jaiswal , Reenu Choudhray , Mohammad Abid , Kamal Kishore
Keywords
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