Criteria for the progression of steatohepatosis in obese adolescents with signs of metabolic syndrome
Journal Title: Здоров`я дитини - Year 2019, Vol 14, Issue 6
Abstract
Background. To date, obesity in adolescents is a serious problem, which is caused by the prevalence of this pathology, especially in developed countries, and the possible consequences in the future, in particular, metabolic syndrome. It was believed that metabolic syndrome is diagnosed in middle-aged people and in the elderly, but modern studies suggest that this pathology is increasingly manifested in adolescents, and the liver is a key organ of the pathogenesis of all metabolic disorders. Therefore, the study, which aims to determine the algorithm for the progression of steatohepatosis in obese adolescents with signs of metabolic syndrome, is relevant. Materials and methods. The study included 226 obese patients aged 12–18 years. To assess the functional state of the liver, clinical, laboratory and instrumental methods of research were used. The homeostasis model assessment was used as a criterion for insulin resistance. Also, serum levels of fibronectin, type IV collagen, N-terminal propeptides and C-terminal telopeptides of type I collagen were evaluated. To determine the criteria for the diagnosis of steatohepatosis in adolescents, Wald-Genkin procedure was used. Results. The results of basic researches (laboratory and instrumental) demonstrate the presence of impaired liver function in obese adolescents, which manifest themselves in the form of fatty liver disease. The revealed atherogenic dyslipidemia, presence of insulin resistance, abdominal obesity make it possible to determine the risk groups for the development of metabolic syndrome among adolescents. The diagnostic value of biochemical markers of fibrosis in non-alcoholic fatty liver disease was studied. The developed algorithm for the early diagnosis of steatohepatosis in obese adolescents confirmed its diagnostic value and reliability, which will contribute to the timely treatment of the disease and the prevention of complications. Conclusions. In the future, the use of the developed algorithm will improve the efficiency of early diagnosis of fatty liver disease, as well as the treatment and preventive measures.
Authors and Affiliations
L. A. Strashok, O. V. Buznytska
Keywords
Related Articles
- EP ID EP666677
- DOI 10.22141/2224-0551.14.6.2019.179244
- Views 82
- Downloads 0
Anxiety and Emotional Aspect of Bronchial Asthma in School Age Children
An examination of 121 children with bronchial asthma (BA) and 226 healthy adolescents aged 12.98 ± 2.80 and 12.36 ± 2.80 years, respectively, was conducted. The aim of the study: to explore the personal and psychological...
The Incidence of Lesions of Different Systems and Organs in Children with Gastroesophageal Reflux Disease
Introduction. Gastroesophageal reflux disease (GERD) — a chronic recurrent disease caused by the disturbances of the motor-evacuating function of the gastroesophageal zone and is characterized by spontaneous and/or regul...
The Possibilities of Acute Bronchopulmonary Diseases’ Monitoring Based on Analysis of Expired Breath Condensate
There were examined 74 children aged from 6 to 18 with complicated and lingering community-acquired pneumonia in order to increase the quality of medical and diagnostic services. Diagnosing and treatment of patients were...
Additional Medical Support of Antibiotic Therapy: the Need or Polypharmacy? Part 2
The article deals with the questions of efficacy and safety of antibacterial agents use, as well as the tactics of prevention of drug allergy in patients receiving antibiotics. The algorithm of the doctor’s actions when...
Current Aspects of Antibiotic Therapy of Community-Acquired Pneumonia in Children of Early and Preschool Age (Review)
In this article we analyzed current antibiotic resistance of S.pneumoniae. We showed local (region) data on sensitivity of pneumococcus to aminopenicillins, macrolides and cephalosporines traditionally used in schemes of...