Crp And Uric Acid Levels As Aprognostic Markers In Acute Myocardial Infrction

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Crp And Uric Acid Levels As Aprognostic Markers In Acute Myocardial Infrction

Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3

Abstract

Introduction: Cardiovascular disease is responsible for 30% of all deaths in the world. About 80% of the global burden of CVD death occurs in low and middle income countries. India carries a significant portion of this CVD burden. Acute myocardial infarction continues to be the major public health problem in the industrialized and developing countries like India despite progressive research in diagnosis and management over last three decades. Until now, various bio-markers have been studied in patients of acute coronary syndrome. However, no single marker gives definite prognostic information during the course of the disease. Little information is available about the role of different individual bio markers. Hence a study is attempted using two easily measured, broadly available biomarkers namely serum Uric Acid, and C-reactive protein targeting different risk indicators like purine metabolism, and inflammation as a tool for assessment in Acutemyocardial infarction. objectives 1)To assess serum c-reactive protein and serum uric acid levels determined on admission as a potential predictor in acute myocardial infarction (AMI) patients. 2)To see for correlation with CRP and hyperuricaemia with Killip’s class and mortality. Source of data: Source of data: All cases admitted to ICCU in Basaveshwara Teaching and GeneralHospital attached to M.R. Medical College, Kalaburagi with acute myocardial infarction. Study design: It is a prospective case control study from BTGH during study period fromDec 2014 to May 2016. A minimum of 100 cases which were diagnosed as acutemyocardial infarction and 100 controls who were healthy volunteers taken. Materials& methods: All cases and controls were taken from BTGH Gulbarga by applyinginclusion andExclusion criteria Results 1. A total of 100 patients were who presented with acute myocardial infarction and 100 controls who are healthy people who came to Basaveshwara teaching and general hospital studied. 2. 75 % were males and 25 % were females. The male to female ratio was 3:1. 3. Majority were in the age group of 51-70 years (59%) both in cases and controls27% belonged to 31 -50 years, followed by 14 % in 61-85 years. Mean age was58.5 years. In control group it is 57.1 years. 4. Most common presenting complaint is chest pain 66%, followed by 32% patients presented with both chest pain and dyspnea. 5. Out of 100 patients, 54% patients were overweight, 9% belonged to obesity class I, 3% to obesity class II and 34% of study population had normal BMI. 6. Dyslipidemia was the major risk factor (79%) followed by hypertension (62%). 7. Out of the 100 patients with AMI 61 % had STEMI, 39 % patients had NSTEMI and AWMI is the most common STEMI seen in 50.8%. 8. Out of 100 patients 59 % patient developed cardiogenic shock, 13.6% developed complete heart block , 18.1 % had ventricular tachycardia and 9% developed ventricular fibrillation. 22 (22%) patients succumbed. 9. Serum uric acid and CRP is significantly elevated in patients with acutemyocardial infarction when compared with controls. 10. Serum uric Acid (>7.5mg %) and CRP> 2.0 mg/dl is associated with highmortality irrespective of day of admission.

Authors and Affiliations

Dr. Srikanth , Md

EP ID EP592492
DOI 10.9790/0853-1603021420
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