Therapeutic efficacy of Iron polymaltose complex versus Ferrous sulphate in treatment of Iron deficiency anemia in children
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Background: Iron deficiency anemia is the most prevalent nutritional deficiency of the world, especially in developing countries. It is estimated that 1.3 billion people suffer from anemia, of which most is due to iron deficiency. Children between 6 to 35 months are particularly high risk group for development of iron deficiency due to low content of bioavailable iron in the weaning foods of developing countries. Obviously for supplementing such young children medicinal iron can be used only in liquid form as drops and syrup formulations. However, there is considerable confusion in deciding on a suitable liquid iron preparation in terms of (a) bioavailability (b) side effect (c) cost effectiveness. Methods: A total of 60 patient were screened, and 50 were enrolled (10 patient did not fulfill the inclusion criteria). 26 patients were assigned to the FS group, and 24 patients were assigned to the IPC group. Inclusion criteria were: age 1-14 years; Haemoglobulin (Hb) < 9g/dL and Serum ferritin < 12 mcg /L. . In one group iron polymaltose was given for 8 weeks in therapeutic dose. The other group received ferrous sulphate for 8 weeks. The primary efficacy parameter was the proportion of patients achieving normal Hb level (>11 g/dL) in the treatment groups within 8 weeks of treatment. Other efficacy parameters were packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobulin (MCH), and mean corpuscular haemoglobulin concentration (MCHC), serum iron, and serum ferritin. Results: The increase in Hb and PCV value was statistically significant when baseline vs. 8-week values were compared in both groups. There was significant (p< .001) increase in MCV level in both groups at the end of 8 weeks. At the end of 8 weeks of either study treatment, there was a statistically significant increase in both MCH and MCHC value from baseline in both treatment groups, but there was no difference between the two treatment groups. The adverse effects were more common in the FS group than the IPC group [20 (77%) in the FS group vs. 7 (29) in the IPC group, P < .001] .The compliance rate was higher than 80 % in both groups. It was significantly higher (P < .05) in the IPC group (91%) than in the FS group (87%). Conclusions: Thus IPC is effective in the treatment of iron deficiency anemia in children. A superior tolerability profile to that of the conventional iron preparation (FS) and an equivalent efficacy profile strongly suggest that it can be considered as a useful, relatively novel, and alternative formulation for the treatment of IDA during childhood
Authors and Affiliations
Dr Partha Kumar Chaudhuri, Dr Anil Kumar Chaudhary
Keywords
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- EP ID EP238855
- DOI 10.9790/0853-1611072729
- Views 115
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