Cryptococcal Cellulitis in a Diabetic with Nephropathy on Adalimumab Therapy for Rheumatoid Arthritis
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2017, Vol 7, Issue 3
Abstract
Cutaneous infection with Cryptococcus neoformans is rare but can occur in the setting of rheumatoid arthritis due to immunosuppression. Risk factors include chronic kidney disease and use of tumor necrosis factor-alpha (TNF-α) inhibitor adalimumab. We report the fourth case of primary cutaneous cryptococcosis (PCC) in a diabetic female more than 60 years old living in rural Northwest Tennessee and taking adalimumab for rheumatoid arthritis. In a literature review of existing cases, this is the second case involving simultaneous chronic kidney disease and the first case in a diabetic and following extended TNF-α inhibitor immunosuppression monotherapy. Physicians should consider cryptococcal infection in a patient who develops cellulitis that is unresponsive to empiric therapy. In addition, it is imperative to monitor rheumatoid arthritis patients taking adalimumab closely and consider alternative agents in those with pre-existing immunosuppression or known risk factors for opportunistic infections as primary prevention. J Microbiol Infect Dis 2017; 7(3):160-163
Authors and Affiliations
Christine A. Moore, Imranali Khan, Almira Opardija, Parasbhai D. Patel
Keywords
Related Articles
- EP ID EP413779
- DOI 10.5799/jmid.367623
- Views 109
- Downloads 0
Frequency of active HCV infection among anti-HCV positive patients in selected districts of Khyber Pakhtunkhwa, Pakistan
Objective: The objective of this study was to determine frequency of active HCV infection among confirmed anti-HCV positive subjects of KPK in order to help the infected subjects decide about anti-viral treatment options...
Prevalence of carbapenem resistant Enterobacteriaceae from a tertiary care hospital in Mumbai, India
Objective: The emergence of Carbapenem Resistant Enterobacteriaceae (CRE) in recent times has become a serious threat to public health due to the high mortality, potential dissemination rates and limited treatment option...
Use of alternative product in patients with chronic viral hepatitis
Objectives:Some of the patients with chronic hepatitis use both alternative product and/or antiviral treatment. These herbal products sometimes lead to clinical deterioration. In this study we aimed to determine the purp...
Rothia mucilaginosa Bacteremia Associated with HIV and Non-Hodgkin’s Lymphoma: A Case Report and Brief Review of Literature
Rothia mucilaginosa is part of the normal flora of the oral cavity and is typically is not associated with acute infection. However, growing evidence suggests that Rothia mucilaginosa can be an opportunistic pathogen in...
Profile of Person Affected by Leprosy with Clinical Relapse among in High Endemic State of India
Profile of Person Affected by Leprosy with Clinical Relapse among in High Endemic State of India Sunil Vilasrao Gitte1, Chaitanya Nigam1, Ashish B Chakraborty1, Krishnamurty Kamble1, Mukesh Soni1, Rupam Gahlot2 1Regional...