Cubosomes: The Inimitable Nanoparticulate Drug Carriers
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 6
Abstract
Cubosomes consist of honeycombed (cavernous) structures separating two internal aqueous channels and a large interfacial area. Cubosomes are nanoparticles which are self assembled liquid crystalline particles of certain surfactants with proper ratio of water with microstructure that provides unique properties of practical interest. Bicontinuous cubic liquid crystalline phase is optically clear and very viscous material has the unique structure at nanometer scale. The word bicontinuous refers to the division of the two continuous but non-intersecting aqueous regions by lipid bilayer that is twisted into space filling structure. Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. Self-assembled cubosomes as active drug delivery systems are receiving more and more attention and interest after the first discovery and nomination. They exhibit different internal cubic structure and composition with different drug-loading modalities. It has high internal surface area and cubic crystalline structures, relatively simple preparation method, biodegradability of lipids, the ability of encapsulating hydrophobic, hydrophilic and amphiphilic substances, targeting and controlled release of bioactive agents. Cubosomes are having wide range of applications in various fields and they can be characterized by various evaluation parameters. So, Cubosomes are gaining more attention by pharmaceutical development sector. Keywords: Cubosomes; Monoleins; Cubic phase; Liquid crystals
Authors and Affiliations
Rohit R. Bhosale, Riyaz Ali Osmani, Bhargav R. Harkare, Prasanna P. Ghodake
Keywords
Related Articles
- EP ID EP378524
- DOI -
- Views 100
- Downloads 0
Formulation and In-Vitro Evaluation of Elvitegravir Fast Disintegrating Tablets
Abstract: Elvitegravir is an antiretroviral drug which belongs to BCS class-II of Biopharmaceutics classification. In the present work an attempt has been made to prepare solid dispersion of elvitegravir by using polyeth...
In-vivo Evaluation of Antidiarrhoeal Activity of Ethanolic Extract of Uraria lagopoides (L.)
Uraria lagopoides (L.) (Papilionaceae), a trailing perennial herb locally known as ‘Prisniparni’ finds use as a remedy for several ailments. The purpose of the present study was to evaluate scientifically the anti-diarrh...
Fabricating Hydantoin / Thiohydantoin Hybrids from A Natural Product, Cuminaldehyde: New Players for Anti-Convulsant Therapeutics
While designing some anti-convulsant hybrid molecules from a natural product, novel hydantoin(5) / thiohydantoin (8) based analogs were synthesized rationally from cuminaldehyde(1), the principal product of Cuminumcyminu...
In vitro Cytotoxic Activity of Luffa acutangula on Human Neuronal Glioblastoma and Human Lung Adenocarcinoma Cell Lines
In vitro studies were carried out to evaluate the cytotoxic potential of the ethanolic and aqueous extracts of Luffa acutangula against human neuronal glioblastoma cells (U343) and human lung cancer cells (A549). Screeni...
A review on Herbal Excipients and their pharmaceutical applications
The Herbal or natural excipients have a great advantage over their synthetic analogues as these are non-toxic, less expensive and freely available. The increasing awareness about these herbal excipients, which are manly...