Culprit Effect of Oxidative Stress and Dyslipidemia on North Indian Stage I Essential Hypertension Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 7
Abstract
Abstract:Systemic deterioration of biomolecules and increased incidence of oxidative stress play a crucial role in the development of hypertension (HT). In addition, occurrence of dyslipidemia in hypertension significantly contributes the development of cardiovascular disease. In this context, the present study focused on culprit effect of oxidative stress and dyslipidemia on North Indian stage I HT patients in enhancing the risk of cardiovascular disease (CVD). The aim is to estimate the plasma lipid profile, marker of inflammation and oxidative stress in stage 1 hypertension and to determine their role in predicting CVD risk.The study population consists of 40 stage I HT patients (40-55 years) of either sex, recruited as per JNC 7th report and 40 age and sex matched healthy controls. Plasma lipid profile, c-reactive protein (CRP) and ascorbic acid levels were measured along with erythrocyte malondialdehyde (MDA) levels in study group subjects and data was statistically analyzed using standard methods.Plasma total cholesterol, triglycerides, LDL-cholesterol, CRP and MDA levels were significantly high (p<0.05) in patient group as compared to healthy controls whereas plasma ascorbic acid and HDL levels were decreased significantly (p<0.05) in stage I HT patients.¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬¬Thus, enhanced oxidative stress and inflammation along with dyslipidemia play a crucial role in HT development and its related complications. Therefore, these markers should not only regularly monitored with increase in blood pressure but also regulated by effective dietary and therapeutic treatment strategy in early stage of hypertension. Keywords:Malondialdehyde, free radical, inflammation, ascorbic acid, LDL-cholesterol.
Authors and Affiliations
Archana Agarwal, Rahul Saxena
Keywords
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