Cultural validation of the post-Liver transplant quality of life (pLTQ) questionnaire for the Brazilian population
Journal Title: Annals of Hepatology - Year 2016, Vol 15, Issue 3
Abstract
Background and rationale. The post-Liver Transplant Quality of Life (pLTQ) questionnaire, developed in the United States, is adisease-targeted instrument designed to evaluate health-related quality of life (HRQoL) in liver transplant recipients. Our study sought to validate a version of the pLTQ for use in the Brazilian population. Translation and cross-cultural adaptation were carried out in accordance with international standard practices for questionnaire validation. Validity was measured by means of convergent validity (correlations between pLTQ domains and WHOQOL-Bref domains). Reliability was assessed by measurement of internal consistency (Cronbach’s alpha coefficient), reproducibility (intraclass correlation coefficient), sensitivity to change (effect size), and floor and ceiling effects. Results. The study sample comprised 160 liver transplant recipients, with a mean age of 56.9 ± 10.4 years, treated at a tertiary hospital in Southern Brazil. The sample was largely male (62.5%), and the predominant indication for liver transplant was hepatocellular carcinoma (49.4%). Only two questionnaire items were modified during the translation and cross-cultural validationstage. The mean total pLTQ score was 5.58 ± 0.9, with < 20% floor/ceiling effect. Correlations between pLTQ and WHOQOL-Bref domains were acceptable (r = 0.37 - 0.40). For similar dimensions, the correlations between WHOQOL-Bref and pLTQ were statistically significant (p ≤ 0.001). Cronbach’s alpha for the total score was 0.91 (95% CI 0.89 - 0.93), with a range of 0.51 to 0.77 across domains. Reproducibility was 0.90, and sensitivity to change was 0.84. Conclusion. In conclusion, the Brazilian Portuguese versión of the pLTQ exhibited good psychometric performance, suggesting that it can be a useful tool in the Brazilian cultural context.
Authors and Affiliations
Cibele Molski, Edgar Sarria, Rita Mattiello, Sammy Saab, Renata Medeiros, Ajacio Brandão
Keywords
Related Articles
- EP ID EP78578
- DOI 10.5604/16652681.1198810
- Views 124
- Downloads 0
Hepatotoxicity associated with statins
Giant biliary mucinous cystadenoma of the liver
Biliary mucinous cystadenomas (BMC) of the liver are rare benign cystic tumors, however an estimated 20% undergo malignant transformation. They have recently been redefined as mucinous cystic neoplasms in the 2010 WHO cl...
A giant hepatic hemangioma treated successfully with hepatic enucleation
Causes of renal failure in patients with decompensated cirrhosis and its impact in hospital mortality
Background. Renal failure (RF) is reported to occur in 11-49% of the patients with decompensated end-stage liver disease (ESLD) and has been associated with increased mortality, particularly in the occurrence of hepatore...
Dress syndrome and fulminant hepatic failure induced by lamotrigine
Lamotrigine is a non-aromatic antiepileptic drug. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe idiosyncratic reaction to drugs, especially anti-epileptic drugs. Associated clinical featu...