Curcumin Attenuates Neuroinflammation in Parkinsonian Mouse Model
Journal Title: The 2nd Annual Meeting of International Center for Neuroscience Research - Year 2021, Vol 2, Issue 1
Abstract
Parkinson’s disease is an age-related neurodegenerative movement disorder characterized by progressive loss of dopaminergic neurons in substantia nigra pars compacta along with depletion in the dopamine level in striatum. Presently, the treatments available against PD only provide symptomatic relief and have severe side effects establishing a need for better therapies which can provide neuroprotective effects. Hence, researchers are emphasizing on treatment with herbal plants. The ability of curcumin to target multiple cascades, simultaneously, could be held responsible for its neuroprotective effects. The present study was undertaken to investigate the antiinflammatory and anti-oxidative effects of Curcumin in parkinsonian mice model along with its effect on the aggregation of misfolded α-Synuclein protein. The PD mouse model was developed with subcutaneous infusion of Rotenone (2mg/kg b.wt.) administered every day for 35 days in conjugation with oral administration of Curcumin (100mg/kgb.wt.). It was observed that Rotenone stimulated increased expression of the various pro-inflammatory mediators involving TNF-α, IL-6, and IL-1β whereas Curcumin treatment alleviated the effect. The lowering of neural inflammation was seen to ameliorate the aggravated level of ROS production consequently reducing the oxidative stress. This was observed by the augmentation of the GSH level and SOD activity on Curcumin administration. Results of immunoblotting have also suggested the down-regulation of a-synuclein aggregation and up-regulation of the TH protein expression in rotenone-intoxicated mouse. Thus, the results suggest the reduction of oxidative stress, inflammatory response and inhibition of α-synuclein aggregation. Hence, our results suggest that curcumin may be a potential drug in the therapy for PD and other related synucleopathies.
Authors and Affiliations
Aaina Singh Rathore, Prof Surya Pratap Singh*
Keywords
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