Current Antibiotic Sensitivity Pattern of Clinically Isolated Klebsiellapneumonia
Journal Title: Saudi Journal of Biomedical Research - Year 2018, Vol 3, Issue 2
Abstract
Abstract:An increasing antimicrobial resistance among Klebsiellapneumoniae(K. pneumoniae) has been rapidly growing. The cross-sectional, analytical and descriptive study was conducted to investigate the current in vitro susceptibility pattern of clinically isolated K. pneumoniae. Patient data for 700 different clinical specimens were collected from the case records during October 2016 to March 2017. Following isolation and identification of 113 isolates of K. pneumoniae to the species level, antibiotic susceptibility pattern for all isolates was examined using standard Kirby-Bauer disk diffusion method.Among113 K. pneumoniae isolates, 25 (12.6%) and 88 (39.5%) were isolated from outpatients and inpatients respectively were considered for the study. The isolates showed high levels of resistance to Penicillin (100.0%), Ampicillin (96.5), first-generation cephalosporins (>92.0%), Nalidixic acid(93.8%), Erythromycin (96.5), Roxithromycin (99.1%). The isolates were less resistant toAmikacin (27.4%), Imipenem (29.2%). Good antibiotics activity against community-acquired (CA) compared to hospital-acquired (HA) isolates and the difference in resistant rate between them was found statistically significant for several antibiotics. A general increase in the resistance pattern of K. pneumoniae was detected to all the antibioticsthat confirm the greatest and frightening problem in our country. Mechanisms for HA infection control measures must be evaluated to reduce pathogenic resistant bacterial strains spreading. Also, strike regulation of the antibiotics buying and intake by the public need to be applied. Keywords: K. pneumoniae, Antibiotic resistance, Hospital-acquired, Community-acquired.
Authors and Affiliations
TawfiqueKAl Zubiery, Talal Alharazi, Hafez Alsumairy, Adel Al-Zubeiry, Anwar Yusr, Huda Al-shami, Linda Alsaqqaf
Keywords
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