Current Status of Oligometastatic Prostate Cancer: Risk Factors and Treatment Approaches
Journal Title: Üroonkoloji Bülteni - Year 2018, Vol 17, Issue 3
Abstract
Prostate cancer (PCa) is a common disease that causes significant mortality rates. The widespread use of more sophisticated imaging methods has led to the identification of oligometastatic PCa, which has a limited number of metastases. Local therapy (radical prostatectomy and/or radiotherapy) for the primary tumor and metastasis-directed therapies have been proposed. A number of retrospective analyses have been conducted in this patient group to determine the place of systemic treatment, which is still the recommended standard treatment for metastatic disease. These studies were based on the aims of improving survival, protecting the patient from the potential side effects of systemic therapy, and eliminating local prostate-related symptoms. Although the studies were retrospective in nature, a survival advantage has been demonstrated in patients receiving local treatment or metastasis-directed treatments. It has been also shown in these studies that local treatment has no effect, at least no detrimental effect, on non-oncologic outcomes. However, these studies have significant limitations, primarily their retrospective design, differences in definitions and end-points used, and patient selection biases. Nevertheless, these results are clinically valuable and can be utilized in practice in some special cases. This patient group needs comprehensive standardization and risk stratification. Determining the definition, staging, treatment, and which patients will benefit from local treatment is essential. With ongoing prospective studies, it is expected that these uncertainties will be resolved and there will be revolutionary changes in the treatment of oligometastatic PCa in the near future.
Authors and Affiliations
Fuat Kızılay
Keywords
Related Articles
- EP ID EP382526
- DOI 10.4274/uob.1088
- Views 96
- Downloads 0
Tamsulosin Can Improve Lower Urinary Tract Symptoms in Patients Under Active Surveillance Due to Low Risk Prostate Cancer: Prospective Controlled Study
Objective: We aimed to evaluate the efficacy of tamsulosin in the treatment of lower urinary tract symptoms (LUTS) in patients under active surveillance (AS) for low-risk prostate cancer (Pca). Materials and Methods: Pat...
Evaluation of the Side Effect Profile of Intracavitary Bacillus Calmette-Guérin Treatment in Non-muscle-invasive Bladder Cancer
Objective: To reveal the association of side effect profiles seen in patients receiving intravesical bacillus Calmette-Guérin (BCG) immunotherapy for non-muscle-invasive bladder cancer (NMIBC) treatment with patient age...
Socioeconomic Predictors and Patient Perspectives of Prostate-specific Antigen Testing
Objective: To identify important factors affecting men’s decision to undergo prostate-specific antigen (PSA) testing and to determine who is at risk for prostate cancer based on age-specific PSA values. Materials and Me...
The Clinical, Oncological, Functional and Surgical Outcomes of Patients Who Underwent Adrenalectomy
Objective: Adrenal masses are often benign and rarely malignant. They may be also hormonally functional or non-functional. It is possible to treat these masses curatively with open and laparoscopic adrenalectomy. The aim...
Risk Factors for Urothelial Cancers
Urothelial cancers affect renal pelvis and ureters in the upper urinary tract, however they affect bladder and urethra in the lower urinary tract. The rate of the urothelial carcinoma makes up 3% pf cancers in the world....