Tamsulosin Can Improve Lower Urinary Tract Symptoms in Patients Under Active Surveillance Due to Low Risk Prostate Cancer: Prospective Controlled Study
Journal Title: Üroonkoloji Bülteni - Year 2019, Vol 18, Issue 3
Abstract
Objective: We aimed to evaluate the efficacy of tamsulosin in the treatment of lower urinary tract symptoms (LUTS) in patients under active surveillance (AS) for low-risk prostate cancer (Pca). Materials and Methods: Patients who underwent prostate biopsy between 2010 and 2014 were evaluated prospectively. Inclusion criteria for AS were PSA level below 10 ng/mL, a tumor in a maximum of two cores, a tumor core percentage below 50%, a clinical stage ≤ T2a and a Gleason score ≤6. Patients under AS with LUTS were included in the study group and patients with benign pathology results with LUTS were included in the control group. International prostate symptom score (IPSS) and uroflowmetry test were used to evaluate LUTS. The maximum flow rate (Qmax) was recorded. All patients received tamsulosin 0.4 mg once daily in a modified-release formulation (Flomax MR®, Astellas, Japan). Transurethral resection prostatectomy (TUR-P) was performed when surgical treatment was necessary for obstruction despite tamsulosin treatment. Results: The study included a total of 91 patients, 41 patients in the AS group and 50 patients in the control group. Patients were assessed after six months. There was a 30% reduction in IPSS in the AS group and 24.5% in the control group (p=0.591). Qmax increased by 20.4% in the AS group and by 20% in the control group (p=0.985). The need for TUR-P was similar between the two groups (14.6% vs 20%, p=0.503) during three-year follow-up. Conclusion: Tamsulosin can be used safely and with high efficacy for LUTS in patients under AS for low-risk Pca. The improvement in IPSS and Qmax, and the need for surgical treatment were similar to the control group.
Authors and Affiliations
Ayhan Dalkılıç, Göksel Bayar, Muhammet Fatih Kılınç, Abdulmecit Yavuz, Orhan Tanrıverdi, Kaya Horasanlı
Keywords
Related Articles
- EP ID EP634292
- DOI 10.4274/uob.galenos.2018.1189
- Views 110
- Downloads 0
Association Between Postoperative 3rd Month Renal Function After Radical Cystectomy and Preoperative Factors, Oncologic Outcomes, and Complications
Objective: We aimed to investigate the influence of preoperative factors on postoperative renal function and the association between renal function and oncologic outcomes and complications after radical cystectomy (RC)....
Oncocytic Adrenocortical Carcinoma: A Rare Case Report
Oncocytic neoplasms of the adrenal cortex are uncommon and generally benign and non-functioning. About 20% of adrenocortical oncocytic neoplasms show malignant components. A 39-year-old woman with an adrenocortical oncoc...
Information about Prostate Cancer for Urologist: Ga-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography Scintigraphy
Recently, prostate-specific membrane antigen (PSMA), a glutamate carboxypeptidase II enzyme, has transformed intoan excited radiopharmaceutical agent as a result of radiolabeling of small peptides that are developed for...
Is Preoperative Neutrophil Lymphocyte Ratio a Reliable Prognostic Parameter for Localized Prostate Cancer?
Objective In spite of all efforts, prostate cancer is still the 2nd highest cause of cancer-related deaths in men. For this reason new developments are needed in diagnosis, treatment and follow-up of prostate cancer. Neu...
Transperitoneal Laparoscopic Nephrectomy-Our Initial Experiences
Objective: To evaluate the first experiences of laparoscopic nephrectomy operations performed in our clinics. Materials and Methods: A total of 61 laparoscopic nephrectomy operations were performed in our clinics during...