Cycloalkanecarbaldehydes in synthesis of novel 1,2-benzoxathiin-4(3H)-on 2,2-dioxide derivatives and study of the antimicrobial activity of synthesized compounds
Journal Title: ScienceRise: Pharmaceutical Science - Year 2017, Vol 0, Issue 6
Abstract
<p><strong>Purpose: </strong>This paper is dedicated to the investigation of cycloalkanecarbaldehydes, 1,2-benzoxathiin-4(3H)-on 2,2-dioxide and active methylene nitriles interaction and to studying antimicrobial properties of the obtained compounds.</p><p><strong>Methods: </strong>As initial products were used cycloalkanecarbaldehydes 1,2-benzoxathiin-4(3H)-on 2,2-dioxide and active methylene nitriles. During the course of the research were applied the methods of organic synthesis. The structures of the obtained compounds were confirmed by elemental analysis and <sup>1</sup>H NMR spectroscopy. The antimicrobial activity was measured with the agar “well” diffusion method.</p><p><strong>Results: </strong>New 2-amino-4H-pyrans were synthesized by three-component reaction of cycloalkanecarbaldehydes, 1,2-benzoxathiin-4(3H)-on 2,2-dioxide and malononitrile. The replacement of the latter with ethylcyanoacetate in the case of cyclohexanecarbaldehyde led to the isolation of triethylammonium3-[(4-hydroxy-2,2-dioxido-2,1-benzoxathiin-3-yl)(cyclohexyl)methyl]-2,1-benzoxathiin-5-olat 2,2-dioxide. Based on this result and considering originality of such ammonium salts the latter were purposefully synthesized with two-component approach using a range of secondary and tertiary amines. The synthesized compounds demonstrated higher antimicrobial activity than the reference drugs against the gram-positive strains.</p><p><strong>Conclusions: </strong>The current research showed the prospective pathway for the expanding of the existing 2-amino-4H-pyrans diversity by utilizing in their synthesis such enolnucleophile and carbonyl compounds as 1,2-benzoxathiin-4(3H)-one 2,2-dioxide and cycloalkanecarbaldehydes respectively. The revealed antimicrobial activity of the obtained compounds against gram-positive microorganisms gives the opportunity for further investigations of narrow spectrum antibiotics among this group</p>
Authors and Affiliations
Galyna Grygoriv, Dmytry Lega, Valentine Chernykh, Tetyana Osolodchenko, Leonid Shemchuk
Keywords
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- EP ID EP647874
- DOI 10.15587/2519-4852.2017.119279
- Views 170
- Downloads 0
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