Cyclophosphamide and Doxorubicin Induced Melanonychia: A Case Report
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 1
Abstract
Chemotherapeutic agents may rarely cause discoloration and hyperpigmentation of the nails. We present a patient who developed blackish discoloration of nails also referred as melanonychia during six cycles of R-CHOP chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) for the treatment of Non Hodgkin Lymphoma (NHL) follicular type. The patient developed blackish brown discoloration in all the nails. As suggested by previous literature evidence the melanonychia could be associated with cyclophosphamide and doxorubicin. According to the Naranjo causality assessment scale, we established that there was a ‘probable’ association of nail discoloration with the drug.
Authors and Affiliations
Vivek Bhanubhai Prajapati, Sharath Madhyastha, Raviraj Acharya, Vinaya Gopalaswamy, AKHILA DODDAMANI
Keywords
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- EP ID EP328364
- DOI 10.7860/JCDR/2017/23041.9216
- Views 168
- Downloads 0
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