Cyclosporine in Acute Severe Ulcerative Colitis - Effective Rescue for the Economically Challenged
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 3
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with upto one fourth patients suffering from acute exacerbation of their disease. Steroids have been the mainstay of therapy but 30-40% patients are resistant to steroids, requiring either infliximab or cyclosporine. We describe three cases of severe acute UC managed with cyclosporine (parenteral followed by oral) in patients who were refractory to steroids and one patient was even refractory to infliximab. These three patients responded well to cyclosporine and were in clinical and endoscopic remission on follow up. The management of severe UC with cyclosporine highlights a viable, cost effective alternative to biological therapy in such cases
Authors and Affiliations
Atul Kumar Sood, Manish Manrai2, Atul Jha3
Keywords
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