Chemical Composition, Free Radical Scavenging And Antifungal Activity of Zanthoxylum Leprieurii Essential Oils Against Epidermophyton Floccosum And Microsporum Gypseum, two Most Prevalent Cutaneous Mycosis
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 1
Abstract
Background: These investigations were carried out to analyze the chemical composition, to evaluate the radical scavenging, and the anti-fungal activities of essential oils from leaves and fruits of Zanthoxylum leprieurii. Methods: Oils were obtained by hydro distillation using a Clevenger type apparatus. The compounds were identified by gas chromatography and gas chromatography coupled with Mass Spectrometry. Antifungal activity of the essential oils was tested in vitro against Epidermophyton floccosum and Microsporum gypseum while free radical scavenging activity evaluation was done using 2,2 diphenyl picrylhydrazyl method. Results: Results showed that, the major components of the leaves oil were (E)-ß-ocimene (91.5 %) while the most abundant components from fruits oil were also (E)-ß-Ocimene (90.3 %) with pinocarveol (2.8%) and myrcene (2.3 %). The total growth inhibition of the pathogens by fruits essential oil occurred at 4000 ppm and 3000 ppm respectively, for Epidermophyton floccosum and Microsporum gypseum. The leaves oil exhibited total growth inhibition at 4000 ppm against both pathogens. These oils also showed antioxidant activities with SC50 values at 0.77 g/L and 1.80 g/L respectively, for fruits and leaves. There were positive and significant correlations between mycelia growth inhibition of both pathogens and the antioxidant activities of the tested oils. Conclusion: These results showed that, Z. leprieurii essential oils could be used as a source of antioxidant and antidermatophitic compounds which may find applications in pharmaceutical industries.
Authors and Affiliations
Tchabong1 . , S. R. , Sameza1, M. L. , Tchameni, N. S. , Mounbain, F. ,Mouelle, ,S. A. , Jazet1, D. P. M. , Menut3, C Tchoumbougnang4
Keywords
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