Cystatin C: A Marker of Renal Function
Journal Title: Journal of Enam Meical College - Year 2014, Vol 4, Issue 2
Abstract
The most widely used investigation of renal function and GFR is the measurement of serum creatinine and creatinine clearance rate. This has been extremely popular in clinical medicine despite formidable difficulties associated with its quantification and interpretation. The main pathophysiological difficulties include variations in the rates of creatinine generation and its secretion by the renal tubules. Concentration of serum creatinine is now recognized as an unreliable measure of kidney function as it is affected by age, body weight, muscle mass, race and various medications. Several equations have been developed to improve the accuracy of serum creatinine level as a measure of GFR. The most widely used in adult populations are the Cockroft-Gault equation and the abbreviated Modification of Diet in Renal Disease (MDRD) equation. Even with these equations, measurement of GFR is difficult because the equations are less accurate with higher levels of kidney function and are affected by interlaboratory variation in measuring creatinine level. In the above perspective, cystatin C concentration has become a promising marker for kidney function in both native and transplanted kidneys. Because of the possible potentiality of cystatin C to be an emerging endogenous marker for quick and accurate assessment of renal function, we have decided to review elaborately on cystatin C as a marker of renal function and to review the sensitivity and specificity of cystatin C as an endogenous marker compared to serum creatinine. Results of our review study suggest that cystatin C is a better marker of renal function compared to serum creatinine and other endogenous markers irrespective of age, sex and clinical condition.
Authors and Affiliations
Md Aminul Haque Khan, Nasreen Chowdhury, Md Mozammel Hoque
Keywords
Related Articles
- EP ID EP36198
- DOI https://doi.org/10.3329/jemc.v4i2.19680
- Views 343
- Downloads 0
Rheumatological Manifestations of Diabetes Mellitus ─ An Update
Diabetes mellitus (DM) is a chronic metabolic condition and a major public health problem. It is associated with many musculoskeletal manifestations which are usually under-recognized and poorly treated, as compared to...
https://www.banglajol.info/index.php/JEMC/article/view/27766/18497
Nipah virus, a member of the genus Henipavirus, a new class of virus in the Paramyxoviridae family, has drawn attention as an emerging zoonotic virus in South-East and South Asian region. Case fatality rate of Nipah vi...
Asymptomatic Hydatid Cyst in a 30-year-old Female
A 30-year-old female presented in the outpatient department of Orthopedics with the history of low backache for 1 month. Physical examination revealed normal findings. A plain radiography of lumbo-sacral spine showed...
Raised Vaginal Fluid Fibronectin Level Indicates Premature Rupture of Membrane
Background: Premature rupture of membrane (PROM) is one of the common complications of pregnancy that has major impact on fetal and neonatal outcome. It is the commonest clinical event where a normal pregnancy becomes...
The Current Researches on T Follicular Helper Cells and Associated Diseases
T follicular helper (Tfh) cell is a new subpopulation of CD4+ T cell family, whose differentiation is affected by Bcl-6, Blimp-1, STAT3, STAT5 and so on, and it could affect or decide the development of other subsets o...