Cystatin C Associates with Metabolic Syndrome and Cardiovascular Events
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Cystatin C is a serin protease inhibitor and secreted from all nucleated cells in the body. The present study was performed to evaluate the association of serum cystatin C level with metabolic syndrome and cardiovascular events in 5 years follow up period. Method and materials: This study was consisted up 187 patients at the beginning of the study. After 5 years, 154 patients were re-evaluated and 33 were missed. Patients were divided into two groups according to the absence and presence of cardiovascular events as Group A and B. Initial metabolic and biochemical parameters were analyzed. Metabolic syndrome compounds were evaluated. Estimated glomerular filtration rate based on serum creatinine and cystatin C were calculated. Results: Mean cystatin C level was 0.70 ± 0.18 mg/ml in group A and 0.98 ± 0.40 mg/ml in Group B, (p<0.001). Estimated glomerular filtration rate based on creatinine and cystatin C values were statistically significant decreased in group B, (p<0.001). Metabolic syndrome was determined 42.5% of Group A and 87.8% of Group B, (p<0.001). Multivariate logistic regression analysis pointed out that serum creatinine and cystatin C based on glomerular filtration rate are independent risk factors for cardiovascular events. Conclusion: Initial serum cystatin C level and cystatin C based on glomerular filtration rate are independent risk factors for cardiovascular events.
Authors and Affiliations
Arzu Cennet Işık, Süleyman Ahbab, Betül Çavuşoğlu Türker, Mehmet Emirhan Işık, Maksude Hanedar Kılıç, Hayriye Esra Ataoğlu
Keywords
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