Cystatin C, oxidative stress and body fat distribution in the middle aged individuals with coronary artery disease
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Oxidative stress plays an important role in the progression of atherosclerosis it is the principal cause for coronary artery disease CAD Lipid peroxidation product Malondialdehyde MDA is an index of oxidative stress To assess the oxidative stress MDA and total antioxidant capacity TAC are estimated Body fat distribution was assessed by obesity and blood lipids which in turn was measured by Body mass index BMI and waist circumference WC Cystatin C was measured as an emerging cardio vascular risk factorMaterials and Methods Study consists of two groups 145 subjects diagnosed with CAD are included in study group and 66 age and sex matched subjects non CAD are included in control groupResults In this study Cystatin C is highly significant observed in CAD cases than controls BMI and WC are not significantly increased whereas significant increase in mean MDA and decrease in mean TAC levelsConclusion Oxidative stress is markedly observed in CAD cases due to toxic effects of ROS Increase in Cystatin C levels significantly correlated with WC in middle aged individualsKeywords Coronary artery diseases Cystatin C Malondialdehyde Oxidative stress Total antioxidant capacity
Authors and Affiliations
P Srilakshm, Y V Ramakrishna Reddy, K Rambabu, S Venkat Rao
Keywords
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- EP ID EP475446
- DOI 10.18231/2394-6377.2018.0132
- Views 84
- Downloads 0
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