Evaluation of serum uric acid in type two diabetic nephropathy patients
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Diabetic nephropathy is one of the leading complications of longstanding diabetes mellitus With the background of inflammation there is need for laboratory tests for early diagnosis and prevention of diabetic nephropathyMaterials and Methods A cross sectional study done after screening patients satisfying the inclusion and exclusion criteria 50 patients of type II diabetic patients with nephropathy Group I and 50 type II diabetic patients without nephropathyGroup II were included in the study Serum uric acid was estimated by standard enzymatic uricase method on autoanalyser ADVIA 1800 Serum urea was estimated by urease method and serum creatinine was estimated by Jaffes method and SrUric Acid by uricase method using fully autoanalyzer ADVIA 1800Results The mean age in group I was 59 928 years and group II was 562 1147 years The serum Uric Acid was 951 246 mgdl in group I and statistically significant p 168 mgdl The Serum creatinine in group I 668 294 mgdl and statistically significant p 077 mgdl There was positive correlation between SrUric Acid and Sr Creatinine r0625 pConclusion Regular detection can help the clinician to take appropriate action to delay complications which in turn may help preserve renal function in DN patientsKeywords Creatinine Urea Fasting blood glucose Urine albumin
Authors and Affiliations
Guha Niyogi NI, Baviskar P. A, V W Patil, Bagle T. R
Performance verification and sigma metrics of creatinine assays
Introduction: Creatinine enzymatic method is more accurate but its own higher cost is the main reason why the use of Jaffe assays is still in practice. The verification step is performed because assay procedure confirms...
Cross sectional comparative study of serum free iron in type 2 diabetes mellitus patients with and without retinopathy and nephropathy complications
Introduction: Non protein Bound iron has the capacity to generate reactive oxygen species is called Free iron causing lipid peroxidation and protein oxidation. Free radicals have been implicated in the pathogenesis of di...
Diabetes Accelerates Age- Related Lipid Profile Disturbances in Cardiovascular Complications
Cardio Vascular Complications (CVC) are predominant problems both in ageing and diabetes. The present study focuses on the effect of human ageing and diabetes, with special reference to serum lipid profile levels during...
Association between Serum Uric Acid Levels and Hypertension: A Retrospective Study
Introduction: Elevated uric acid levels are frequently associated with lifestyle related diseases. Serum uric acid levels also have shown to play a very important role in the development of cardiovascular morbidity and r...
A comparative study on the estimation of serum Creatinine levels by Jaffe's and Enzymatic methods at different levels of serum Bilirubin
In the present study, based upon their total serum bilirubin values ranging from 0.3-30.8 mg/dl, 47 patients visiting OPD and IPD of HIMS were divided into five groups. Their serum creatinine levels were estimated by the...