Cystic Sertoli-Leydig Cell Tumour in a Postmenopausal Woman with Absent Virilising Symptoms: A Diagnostic Challenge
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
A 60-year-old postmenopausal woman, presented with a left ovarian cystic mass with mildly elevated CA125 levels. An intraoperative frozen section showed oedematous ovarian stroma with interspersed large aggregates of spindle shaped stromal cells. Subsequently, the excised specimen was reported as Sertoli-Leydig Cell Tumour (SLCT) of intermediate differentiation. The leydig cells were identified in the imprint smears, but were misinterpreted as luteinized cells. The lack of tubular differentiated cells in frozen section had contributed to the misdiagnosis. Immunohistochemistry (IHC) played an important diagnostic role in the absence of clinical suspicion and lack of virilising features that are classically described in association with SLCTs. This case is unusual, as the tumour was seen in a postmenopausal woman in the absence of virilising symptoms. The cytomorphological features, IHC findings and the reasons for misdiagnosis are discussed in this case report.
Authors and Affiliations
Vidya Monappa, Saritha M Reddy, Ranjini Kudva, Muralidhar V Pai
Keywords
Related Articles
- EP ID EP342073
- DOI 10.7860/JCDR/2017/26173.9901
- Views 43
- Downloads 0
Effect of Green Coffee Bean Extract on Streptococcus mutans Count: A Randomised Control Trial
Introduction: Mouth rinses have been popularly used as a supplementary oral hygiene aid. A lot of commercially available mouth rinses possess few adverse effects, which has necessitated the search for alternative and her...
Pseudo Aneurysm of Aberrant Right Gastroepiploic Artery Mimicking Pseudocyst of Pancreas– A Rare Case Report
Pseudoaneurysm of peripancreatic vessel is a rare complication of pancreatitis. The splenic artery is the most commonly affected vessels close to the pancreas. Pseudoaneurysm of right gastroepiploic artery is rare. It ca...
A Study of Haematological and Haemostasis Parameters and Hypercoagulable State in Tuberculosis Patients in Northern India and the Outcome with Anti-Tubercular Therapy
Introduction: Tuberculosis is one of the leading infectious diseases with high morbidity and mortality in the developing countries. Tuberculosis is also rarely associated with hypercoagulable state and very limited liter...
Evaluation of Efficacy of Intravenous Iron Sucrose in Management of Adolescent Iron Deficiency Anaemia
Introduction: Worldwide, most common nutritional deficiency anaemia is iron deficiency anaemia. Anaemia in adolescent girls is defined as blood haemoglobin (Hb) level <12g/dL. The highest prevalence seen in ages of 14-19...
Molecular Subtypes in Locally Advanced Breast Cancer-Do They Have a Preferential Destination?
ABSTRACT Introduction: The patterns of relapse in breast cancer are very much driven by the intrinsic molecular subtypes, which have been studied mainly in early stage breast cancer and have prognostic implications. Aim:...