Cytogenetic Anomalies in Multiple Myeloma Patients: A Single Center Study
Journal Title: Genetics & Applications - Year 2019, Vol 3, Issue 1
Abstract
Conventional karyotyping in the patients with Multiple myeloma (MM) is very important because the detected chromosomal abnormalities have diagnostic and prognostic value. In this retrospective study we aim to evaluate cytogenetic abnormalities in 133 MM patients whose diagnosis was established at the Hematology Department of Hacettepe University. The bone marrow samples were treated with trypsin and stained with Giemsa (GTG banding). For each patient, 20 metaphases were examined and karyotypes were formed. Cytogenetic results of the patient’s bone marrow samples were obtained in 114 patients. Of 114 examined karyotypes, 80 patients had normal karyotype while 34 patients had abnormal karyotypes. Both numerical and structural chromosomal anomalies were detected in patients with abnormal karyotype. The most frequent numerical and structural anomalies were detected in chromosomes 1, 9, 16 and 13. The anomalies we found in our patient group were consistent with the literature.
Authors and Affiliations
Süreyya Bozkurt, Yahya Büyükaşık, Haluk Demiroğlu, Elifcan Aladağ Karakulak, Müfide Okay, Ayşe Karataş, Salih Aksu, İbrahim C Haznedaroğlu, Nilgün Sayınalp, Osman I Özcebe, Hakan Göker
Keywords
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- EP ID EP592359
- DOI 10.31383/ga.vol3iss1pp51-56
- Views 130
- Downloads 0
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