Cytological diagnosis of extramedullary hematopoiesis-presenting as mass-like lesion: A study of four cases
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 5, Issue 3
Abstract
Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside the bone marrow; it occurs in diverse conditions, including fetal development, normal immune responses, and pathological circumstances1. EMH occurs either actively or passively in response to diverse changes in the hematopoietic environment. Both active and passive EMH produce blood cells such as antigen-presenting cells, granulocytes, NK cells, red blood cells, and/or platelets for the growth or survival of the host. EMH sites in adults are most commonly liver, spleen, and lymph nodes2. Objectives: Because of a few nonspecific or occasional lack of clinical signs associated with EMH and its occurrence in almost every organ system and its presentation as a mass-like lesion, recognition of benign trilinear hematopoiesis from aspirations of mass lesions from any site is an important consideration. Case Details: We present four cases of EMH, wherein two of our cases presented with an adrenal mass, which was diagnosed to be myelolipoma and the other two cases were diagnosed incidentally, and further workup of these cases were found to have an underlying hematological disorder. Our cases were subjected to fine needle aspiration cytology (FNAC) under guidance and along with detailed clinical and haematological workup were diagnosed to be EMH. Conclusions: While the bone marrow is the major site of hematopoiesis, it can occur in almost any other tissue of the body. Typical cytomorphology associated with clinical and radiological findings offer a reliable diagnosis of EMH by FNAC.
Authors and Affiliations
Malathi M, Ashwini Naragund, Baalu S, Akkamahadevi Patil
Keywords
Related Articles
- EP ID EP365382
- DOI -
- Views 99
- Downloads 0
The role of Papanicolaou smear in the diagnosis of pathological flora in reproductive age group patients in tertiary care centre
Background: The infections of female genital tract are most common in reproductive age group women. In this the most common are Cervical – Vaginal infections which pose a diagnostic challenge. These infections lead to cy...
Assessment of seroprevalence of viral transfusion transmitted infections among blood donors at a government hospital blood bank with facility of only whole blood
Background: Every blood transfusion carries potential risk of transmitting transfusion transmitted diseases (TTD) to the recipient. Strict criteria are followed while selecting a donor so that proper blood free of all pa...
Cytopathological study of thyroid lesions by fine-needle aspiration cytology at tertiary care center in Saurashtra region
Background: Fine needle aspiration cytology (FNAC) is the easiest, simple and rapid diagnostic procedure amongst all the diagnostic tests for evaluation of thyroid lesions. It is important to diagnose benign and malignan...
Utility of scrape cytology in early diagnosis of premalignant and malignant oral lesions - A study of 100 cases at a tertiary care centre
Background: The oral squamous cell carcinoma [OSCC] is the most common cancer worldwide and constitutes a major health problem in developing countries, representing the leading cause of death. In India it accounts for al...
Can Platelet count helps in suspecting malaria infection?: Data analysis from tertiary care hospital
Background: Onset of Malarial infection frequently presents with non specific symptoms and may resembles with other type of fever of other origin. Malaria is major health problem in India. It usually presents with hromb...