CYTOPROTECTIVE EFFICACY OF DRDE-07 AND DRDE-30 AGAINST CISPLATIN INDUCED NEPHROTOXICITY
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 5
Abstract
Aim: The objective of the study was to investigate the cytoprotective action of DRDE-07 and DRDE-30 against cisplatin induced nephrotoxicity in mice. Subjects and Methods: Randomly bred Swiss female mice (25-30 g) were selected and were divided into five groups (n = 6). Group I treated as control (distil water); Group II were administered Cisplatin at 10mg/kg. And Group III were administered Cisplatin at 10mg/kg and Amifostine (185 mg/kg), Group IV were administered with Cisplatin (10 mg/kg) and DRDE-07 at 249 mg/kg, Group V were administered with Cisplatin (10 mg/kg) and DRDE-30 at 219 mg/kg body weight. Two experiment designs were planned. In first design, drug was given 30 min before administration of cisplatin and followed by three days orally. In second design the drug was given after administration of cisplatin and the rest was same as first design.
Authors and Affiliations
Manoj Sharma*| School of Studies in Pharmaceutical Science, Jiwaji University, Gwalior (M.P.)
Keywords
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