Cytotoxic activity of the selected pyridinium salts against murine leukemia L1210.
Journal Title: Pharmacological Reports - Year 2007, Vol 59, Issue 2
Abstract
The objective of this work was to evaluate the relationship between chemical reactivity of 3-substituted pyridinium salts and their cytotoxic properties against murine leukemia L1210. Chemical reactivity of pyridinium salts towards NADH oxidation following one-step hydride transfer depends strongly on their redox properties. The investigated reaction may reflect the ability of the salts to deplete NADH level in cells and to affect their metabolic functions. On the other hand, the cytotoxic activity against murine leukemia cells, expressed as ED(50) values, varied strongly depending upon the compound used. The investigated salts showed also a diverse antileukemic effect in in vivo experiments as measured by the increase in the survival time of L1210 eukemia-bearing mice. These biological effects were correlated with equilibrium constants found for the reaction of pyridinium salts with NADH.
Authors and Affiliations
Marzena Wieczorkowska, Piotr Szajerski, Radosław Michalski, Jan Adamus, Andrzej Marcinek, Jerzy Gębicki, Ewa Ciesielska, Leszek Szmigiero, Anna Szmigielska-Kapłon, Tadeusz Robak
Keywords
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