Platelet interaction with progenitor cells: vascular regeneration or inquiry?
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 1
Abstract
Increasing evidence supports the role of stem and progenitor cells in vascular regeneration or injury. Following tissue ischemia, progenitor cells are mobilized from their bone marrow or peripheral niches into circulation, adhere at sites of vascular lesion and differentiate into a variety of mature cell types according to their origin and the local environment. Impairment in this pathophysiological process due to either low numbers of circulating progenitor cells or dysfunctional progenitor cells leads to inadequate vascular repair and upon co-existence with different cardiovascular risk factors to vascular injury and atherosclerosis. Vascular repair is a complex process which includes mobilization, chemotaxis, adhesion, proliferation and differentiation of progenitor cells. The common cardiovascular risk factors can impair this process resulting into inhibition of vascular healing and enhancement of inflammatory pathways which ultimately leads to atherosclerosis. Although homing of progenitor cells into bone marrow has been extensively studied, domiciliation of precursor cells into peripheral tissues and differentiation into mature cells are poorly understood so far. Recently, the role of platelets in domiciliation and subsequent differentiation of progenitor cells has been highlighted. Adherent platelets recruit circulating progenitor cells in vitro and in vivo and induce differentiation of the latter into endothelial cells or macrophages and foam cells. Although further studies are needed to describe the mechanisms that lie underneath these observations, it seems that platelet interaction with progenitor cells is an essential step in both vascular regeneration and injury.
Authors and Affiliations
Konstantinos Stellos, Stephan Gnerlich, Bjoern Kraemer, Meinrad Gawaz
Keywords
Related Articles
- EP ID EP154781
- DOI -
- Views 93
- Downloads 0
Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.
This review briefly summarizes the information on the molecular mechanisms of action, pharmacokinetic profiles and drug interactions of novel (third-generation) antiepileptic drugs, including brivaracetam, carabersat, ca...
Protective effects of histamine H(3)-receptor ligands in schizophrenic behaviors in experimental models.
Schizophrenia (SCZ) afflicts around 1% of the world's population with characteristic symptoms such as hallucinations, delusions, and cognitive disorders. Several experimental studies in the past have indicted brain hista...
Trans-4-aminocrotonic acid (TACA), a potent agonist of GABA(A) and GABA(C) receptors, shows a proconvulsant action in the electroconvulsive threshold test in mice.
In the present study, we evaluated TACA (a potent agonist of GABA(A) and GABA(C) receptors) in the electroconvulsive threshold test in mice. Surprisingly, TACA (at 15 and 25 mg/kg) significantly decreased the threshold....
Taurine prevents ethanol-induced alterations in lipids and ATPases in rat tissues.
The study investigates the cytoprotective effect of taurine on ethanol-induced alterations in lipids and enzymes involved in ion-transport in rat tissues. Male albino rats were divided into 4 groups (n = 8) and maintaine...
Effect of administration of etidronate and retinol on bone mechanical properties in ovariectomized rats.
The experiments were carried out on rats, divided into 7 groups: I - sham-operated control rats, II - ovariectomized (OVX) control rats, III - OVX + etidronate (10 mg/kg po), IV - OVX + retinol (700 IU/kg po), V - OVX +...