CYTOTOXIC EFFECT OF PEPTIDE FUNCTIONALIZED SILVER NANOPARTICLES SYNTHESIZED FROM ALOIN ON BREAST CANCER CELL LINE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 2
Abstract
Objective: The aim of the present study is to synthesize the silver (Ag) nanoparticle using Aloin with a focus on its antibacterial, antioxidant, and anticancer activity. Methods: The silver nanoparticles were synthesized using Aloin and were determined by UV-Visible spectrum. It was further characterized by scanning electron microscope (SEM), zeta potential, and dynamic light scattering (DLS). The Fourier transform infrared analysis was also carried out for the Aloin. Results: The UV-Visible absorption spectrum of the synthesized silver nanoparticles has shown the absorption peak at 439nm which proves the formation of silver nanoparticles in the solution. The SEM analysis revealed that the Ag nanoparticles were spherical in shape. The IR spectra showed that there are 6 functional groups are present in Aloin extract. The synthesized nanoparticles are found to be highly stable with an average particle size of 130.7nm which was confirmed by zeta potential and DLS analysis. The synthesized nanoparticles had a good antibacterial and antioxidant activity. It shows a very good cytotoxic effect against breast cancer cell line. Conclusion: The present study suggests that the synthesis route is free from the requirements such as high energy, extended preparation time, and special equipments and thus can be used for large-scale synthesis in food industries for food preservation and these Ag nanoparticles can be used for its therapeutic purposes for developing a new drug against cancer.
Authors and Affiliations
LEEMA ROSE A, VIDHYA S, JANEETA PRIYA F, SABEENA ASHIFA J
Keywords
Related Articles
- EP ID EP608756
- DOI -
- Views 93
- Downloads 0
DEVELOPMENT OF AQUEOUS POLYMERIC DISPERSION (APD) OF EUDRAGIT E PO- PERFORMANCE CHARACTERIZATION FOR AQUEOUS BASED TASTE MASKING COATING SYSTEM
The present research work was performed to develop an Aqueous Polymeric Dispersions (APD) of Eudragit E PO using emulsification solvent evaporation technology including optimization of solvent, emulsifier & stabilize...
DETERMINATION OF 5H-BENZO[2,3][1,4]OXAZEPINO[5,6-B]INDOLES IN RAT PLASMA BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC-ULTRAVIOLET METHOD: APPLICATION TO PHARMACOKINETIC STUDIES
Objective: Recently, we reported newly synthesized 5H-benzo[2,3][1,4]oxazepino[5,6-b]indole) derivatives and proved their cytotoxicity against hepatocellular carcinoma specific Hep-G2 cell lines. We attempted herein to d...
OPTIMUM CONDITIONS FOR N-ACETYL GLUCOSAMINE PRODUCTION FROM TIGER SHRIMP (PENAEUS MONODON) SHELL BY SERRATIA MARCESCENS
Objective: The aim of this research was to determine the optimum condition for Serratia marcescens to produce optimum amount of N-acetyl glucosamine using chitin isolated from tiger shrimp (Penaeus monodon) shells.Method...
ASSESSMENT OF SMOKING BEHAVIOR AMONG MALAY MALE SMOKERS IN KELANTAN, MALAYSIA
Objective: The aim of this study was to assess smoking behavior among Malay male smokers in Kelantan, Malaysia.Methods: Volunteers (n=496) were recruited in the study by randomly selected manner. The participants were ca...
A RAPID QUANTITATIVE DYE-BINDING METHOD OF SCREENING GLYCOSAMINOGLYCANS PRESENCE IN MEDICINAL PLANTS
Objectives: The aims of this paper are to extract glycosaminoglycan (GAG) from four local medicinal plants and to characterize the crude extract with highest total sulfated GAG to reduce the dependency of using animals a...