DEVELOPMENT OF AQUEOUS POLYMERIC DISPERSION (APD) OF EUDRAGIT E PO- PERFORMANCE CHARACTERIZATION FOR AQUEOUS BASED TASTE MASKING COATING SYSTEM
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
The present research work was performed to develop an Aqueous Polymeric Dispersions (APD) of Eudragit E PO using emulsification solvent evaporation technology including optimization of solvent, emulsifier & stabilizer. The basis rationale for the present research is to develop water based coating system over organic solvent based coating systems to achieve certain advantages over organic solvents with respect to ecological, toxicological and manufacturing safety concerns, including Pollution, Explosion hazards, Risk of operators, High cost of organic solvents, solvent toxicity and many more. The APD of Eudragit E PO was developed by emulsification solvent evaporation technology including optimization of Ethyl Acetate as solvent, 1%w/w SLS as emulsifier & 4% w/v Polaxomer F127 as stabilizer. The Concentration of Eudragit E PO was optimized as 15%w/v among three APD formulations F1-5%, F2-10% & F3-15% by optimizing Particle size, pH & Viscosity parameters. The optimized APD (F3-15%w/v APD) was characterized for different parameters viz. Average Particle Size by TEM & found 732 nm, pH by electrode pH meter & found 6.8 & viscocity by brook’s field viscometer & found 0.6 Pascle. The  Optimized APD (F3-15%w/v APD) was characterized for any possible interactions by DSC & FT-IR spectra. Three different free films were prepared with three different plasticizer viz. di-butyl phthalate, propylene glycol and tri-ethyl-citrate to plasticize optimized aqueous polymeric dispersion of Eudragit EPO (F3-15%w/v APD). Tri-ethyl-citrate 30%w/v of dry polymer was optimized for the development of the free films from an optimized APD(F3). The optimized aqueous polymeric dispersion of Eudragit EPO (F3-15%w/v APD) was used for the performance characterization for taste masking coating properties of ofloxacin tablets. APD (F3-15%w/v APD) coated Ofloxacin tablets were comparatively evaluated with Eudragit E PO Organic solvent coated Ofloxacin tablets for different parameters viz. (a.) Physical- Hardness, Friability, Wt. Variation etc (b.) in-vitro dissolution profile- In Distilled water & Simulated Gastric Fluid (SGF) (c.) Biological- Taste masking. The accelerated stability study of optimized APD (F3-15%w/v APD) was also performed for 30 days evaluated for Particle size, Viscosity & Redispersibility. It was concluded that the APD was stable at room temperature & unstable at 4-80C.Key Word: APD, Eudragit E PO, In vitro release study, TEM, FT-IR, DSC, Polaxomer F127.
Authors and Affiliations
Mehta Naveen
Keywords
Related Articles
- EP ID EP605724
- DOI -
- Views 127
- Downloads 0
IN SILICO MODELING OF MONOMERIC DEXAMETHASONE-INDUCED RAS-RELATED PROTEIN 1 AND RAS HOMOLOG ENRICHED IN STRIATUM: ROLE OF N TERMINUS AND STRUCTURE‑FUNCTION RELATIONSHIP
Objective: Dexamethasone-induced Ras-related protein 1 (Dexras1) and Ras homolog enriched in striatum (RHES) are the two monomeric small G proteins that belong to Ras superfamily. These two proteins show 62% similarity....
ANTIMOTOLITY EFFECT OF ORGANIC EXTRACTS OF ANTHEMIS MAURITIANA MAIRE & SENNEN FLOWERS ON THE RODENT ISOLATED JEJUNUM
 Objective: The aim of the present study was to investigate the effect of the organic extracts of Anthemis mauritiana (AM) Maire and Sennen (Asteraceae)flowers on the contractile responses of the rabbit and rat jejunums...
THE FIBRINOLYTIC ALTERATION ASSOCIATED WITH DAILY ADMINISTRATION OF SILDENAFIL
Objective: The objective of this study was to determine the fibrinolytic alteration associated with daily administration of sildenafil.Methods: A total of 12 adult male rabbits without mortality rate had been fed standar...
COMPARATIVE STUDY ON HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY PROFILE AND ANTIMICROBIAL ACTIVITY OF ETHANOLIC AND HYDROALCOHOLIC EXTRACT OF VETIVERIA ZIZANIOIDES L. ROOT
Objective: Scientific evaluation of traditionally using medicinal herbs for their pharmacological activity is a leading and valuable area of research. The aim of this study is to compare the antimicrobial activity of eth...
ANALYSIS REACTIVITY OF PUNICA GRANATUM POLYPHENOLS TO THE OSTEOCALCIN, BONE MORPHOGENETIC PROTEIN-2, AND COLLAGEN TYPE-1
Objective: Punica granatum (PG) contains anthocyanins which are useful as antioxidants, anti-inflammatory, and prevent cancer, while also increasing bone cell proliferation and osteoblasts differentiation in bone remodel...