d-limonene attenuates blood pressure and improves the lipid and antioxidant status in high fat diet and L-NAME treated rats
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 11
Abstract
Obesity and hypertension are important risk factors for cardiovascular diseases. The present study investigates the effect of d-limonene on blood pressure, plasma lipids, circulatory lipid peroxidation byproducts and antioxidants status in young male Wistar rats fed a high fat diet (HFD; 42.2% beef tallow) together with Nω-nitro-L-arginine methyl ester (L-NAME; 80mg/L in drinking water) for 8 weeks and subsequently with 2% dlimonene for the final 4 weeks. HFD fed rats showed increased systolic blood pressure, increased concentrations of circulatory lipids and lipid peroxidation byproducts, increased activities of circulatory enzymic antioxidant and decreased concentrations of nonenzymic antioxidant, L-NAME supplementation further increased systolic blood pressure, lipid concentrations, lipid peroxidation byproducts and enzymic antioxidant and decreased nonenzymic antioxidant. Supplementation of 2% d-limonene to HFD and L-NAME treated rats decreased the blood pressure and reverses the changes in lipids, lipid peroxidation byproducts and antioxidant. d-limonene should be considered as a promising lipid lowering agent and antioxidant activities with blood pressure-lowering properties
Authors and Affiliations
Jesudoss Victor Antony Santiago , Jayaraman Jayachitra , Madhavan Shenbagam , Namasivayam Nalini
Keywords
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