DECEASED DONOR KIDNEY TRANSPLANTATION: A RETROSPECTIVE ANALYSIS FROM A TERTIARY CARE HOSPITAL IN MUMBAI
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 35
Abstract
BACKGROUND Increasing deceased donor kidney donation is the only answer to fill the large gap between availability and need for organ donors. Deceased donor kidney transplant rates are picking up in the Southern and Western regions of India and there is a need to look at the outcomes at various institutes and share the experience. The objective of the study is to evaluate outcomes of deceased donor kidney transplants (DKT) done at a tertiary care centre in Mumbai. MATERIALS AND METHODS In this retrospective study, outcomes of all DKTs done from April 2012 to July 2017 were evaluated. Induction immunosuppression consisted of two to three doses of anti-thymocyte globulin (1.5 mg/kg per dose) and methylprednisolone pulses whereas maintenance immunosuppression regimen consisted of prednisolone, mycophenolate mofetil and tacrolimus. The data was analysed for demographic profile of recipients and donors, comorbidities in recipients, cause of kidney disease in recipients, waiting period on dialysis, delayed graft function, episodes of rejections, induction agents used, maintenance immunosuppressants, infection episodes, patient and graft survival and causes of death. RESULTS A total of 21 DKTs (52.4% male recipients) were performed during the study period. The mean (+ SD) age of recipients and donors was 46.71 (±10.6) and 47.8 (+13.5) years respectively. Incidence of biopsy proven acute cellular rejection was 9.5%. Patient survival at one, three and five years were 90.5%, 84.5% and 84.5% respectively. Four (19.04%) grafts were lost during the study period, three grafts were lost because of death of the patients (two at three months and one at 22 months posttransplant) and only one other graft was lost at 43 months with patient returning to dialysis. Three patients (14.3%) died during the study period; two due to sepsis and one due to cardiovascular disease. CONCLUSION Current study results suggest that DKT can be successfully carried out with good results even with the current limitations.
Authors and Affiliations
Shrirang Bichu, Parag Vasant Tilve, Viswanath Billa, Ashok Kirpalani, Dilip Ashok Kirpalani, Hardik Kirit Shah, Umesh Oza, Mukund Andankar
Keywords
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- EP ID EP571164
- DOI 10.18410/jebmh/2018/525
- Views 77
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