DELTA-TOCOTRIENOL IS THE MOST BIOACTIVE ANTICANCER AGENT AGAINST GASTRIC CANCER
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 11
Abstract
This study evaluated the anticancer activity of δ-tocotrienol (DT3), a bioactive form of vitamin E, in the inhibition of gastric cancer growth and survival compared with other three forms α-, β- and ϒ-tocotrienol (AT3, BT3 and GT3). DT3 is the most bioactive form of vitamin E in inhibiting the cell proliferation of non-metastatic (AGS) and metastatic (746T) gastric cancer cells followed by GT3 and BT3. However, AT3 is devoid of any inhibitory effect on gastric cancer cell viability. The estimated IC50 values are 80+5, 55+5 and 40+5 μM for BT3, GT3 and DT3, respectively in both cell lines. DT3 (40 μM) significantly inhibited malignant transformation (p <0.02, p <0.01), cell migration (p <0.01) and invasion (p < 0.05, p < 0.02) compared to vehicle in AGS and 746T cells. DT3 inhibited markers for epithelial (E-cadherin) to mesenchymal (vimentin) transition (EMT), metastasis (matrix metalloproteinase 9 [MMP9]), angiogenesis (Vascular endothelial growth factor [VEGF]), inflammation (Nuclear factor-kappa B [NF-kB]), and Wnt signaling (β-catenin) and its downstream transcriptional targets C-MYC, Cyclin D1 and survivin compared to vehicle. In addition DT3 also induced apoptosis in gastric cancer cells (AGS and 746T). Taken together, these data demonstrate that DT3 is a potential therapeutic agent in advanced gastric cancer and warrants further investigation for its clinical use in the prevention and treatment of gastric cancer.
Authors and Affiliations
Dr. Kazim Husain
Keywords
Related Articles
- EP ID EP656422
- DOI -
- Views 154
- Downloads 0
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF BENZOXONIUM CHLORIDE AND LIDOCAINE HYDROCHLORIDE
The aim of the present study was to develop and validate reverse phase high performance liquid chromatography (RP-HPLC) method for simultaneous estimation of Benzoxonium chloride and Lidocaine Hydrochloride in bulk and c...
CORRELATIONS BETWEEN HYPERPROLACTINEMIA AND AZOOSPERMIC PATIENTS
Azoospermia, defined as complete absence of sperm from the ejaculate, is present in about 1% of all men, and in approximately 15% of infertile men. The evaluation of a patient with azoospermia is performed to determine t...
FORMULATION AND EVALUATION OF POLY HERBAL FACEWASH GEL FOR ANTI MICROBIAL ACTIVITY
Poly herbal means collecting of different ingredients (exciepients) from different herbal formulations. Curcuma-longa (Linn), family (Zingiberaceae) possessing antibacterial properties are the truth is that most prescrib...
IMPORTANCE OF SESAME OIL IN HERBAL OIL FORMULATION: A REVIEW ARTICLE
Sesame plant holds its importance from the ancient culture. Sesamum indicum commonly called as sesame, Family: Pedaliaceae mainly cultivated for its seeds. Sesamum indicum Linn. (Pedaliaceae) is an annualshrub with white...
DERIVATIVE ULTRA-VIOLET SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ARTEMETHER AND LUMEFANTRINE IN BULK AND FORMULATIONS
A derivative Ultra Violet Spectrophotometric method was developed to estimate Artemether and Lumefantrine simultaneously in bulk as well as in formulations The method is based on comparing area of a first derivative curv...