Dendrimers and their Applications
Journal Title: Pakistan Journal of Pharmaceutical Research - Year 2016, Vol 2, Issue 1
Abstract
Dendrimers are the valuable additives in different routes of drug administration and are the most successful agents, because dendrimers provide greater biocompatibility, water solubility and bioavailability. In this review, synthesis structures, method of preparation have been discussed. Interaction mechanisms between dendrimer molecules and active pharmaceutical ingredient (API), like simple encapsulation and covalent conjugation and the recent applications of dendrimers have also been focused. Divergent method of poly amidoamine (PAMAM) dendrimers is found to be more applicable as compare to convergent method and PAMAM are also considered as ideal carriers for drug delivery because of large variety of surface groups, high aqueous solubility, and their unique architecture.
Authors and Affiliations
Mughisa Munir
Keywords
Related Articles
- EP ID EP200380
- DOI 10.22200
- Views 92
- Downloads 0
Evaluation of inorganic elements in herbal preparations by FAAS and FES
In this study four inorganic elements i.e. sodium, potassium, calcium and magnesium were estimated in eleven locally available herbal preparations used as sex stimulants using Flame Atomic Absorption Spectrometry and Fla...
Screening of hepatoprotective effect of methanolic extract of Solanumnigrum against paracetamol
Solanum nigrum (SN) commonly known as “Makoo” frequently available in most of the areas of Pakistan, is well reputed in the indigenous system of medicine for its medicinal use in liver disorders. The present study was ai...
NANOPARTICLES AS A NOVEL DRUG DELIVERY SYSTEM:A Review
Nanotechnology is showing a significant impact on the drug-delivery system over a past few years. This technology is playing a distinct role in remodeling the future of novel drug delivery system (NDDS). Nanoparticles (N...
A Comparative analysis: In-vitro dissolution study of different commercially available brands of diclofenac sodium
The study was aimed to compare in-vitro release behavior of four commercially available brands of diclofenac sodium sustained release tablets. Most commonly used brands of tablets were taken randomly that contained same...
Thiolation of Polymers; A re-oriented approach towards targeted drug delivery.
Targeted drug delivery remains a challenge for the pharmaceutical scientists due to less solubility of API and less compatibility and contact time of excipients with mucous membrane. Modification in the composition of ex...