DERMATOLOGICAL ADVERSE EFFECTS OF CHEMOTHERAPEUTIC AGENTS: EXPERIENCE FROM A TERTIARY CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 51
Abstract
BACKGROUND Chemotherapeutic agents, both conventional and new targeted therapy, are known to cause diverse side effects related to skin, hair, mucous membranes and nails, collectively called `dermatological adverse effects`. But such association in literature is mostly confined to case reports/case series and small number of published papers. The aim of this study is to look for dermatological adverse effects and the most common culprit agents, with the objective that the oncologist and dermatologist team remain vigilant and adopt rational management protocol in their management to circumvent the morbidity and long-term toxicity as it involves the cosmetic appearance of long-term cancer survivor. MATERIALS AND METHODS This prospective hospital-based descriptive study was conducted jointly by the dermatologist and oncology team over a period of more than one year in a specialised tertiary centre on oncology patients, who developed dermatological side effects after initiation of anti-cancer drugs. RESULTS Out of 125 patients studied, dermatological adverse effects of varying duration were noticed in 27 patients (21.6%), with overall 45 side effects manifestation. Most common among cutaneous manifestations were anagen and telogen effluvium, followed by diffuse hyperpigmentation, xerosis and hand-foot syndrome. Nail discolouration was the most notable nail change, leukonychia being more common than hyperpigmentation, and the most common oral mucosa manifestation was oral mucositis. CONCLUSION Although dermatological adverse effects due to chemotherapeutic agents is commonly recognised, yet most of the times the features are not of such serious nature as to warrant withdrawal of the therapy. But a thorough knowledge is essential to alleviate the apprehension arising as a result of it and to improve the overall outcome of patients.
Authors and Affiliations
Parvaiz Anwar Rather, Hussain Mir M, Sandeep Kaul, Vikas Roshan, Jilu Mathews, Bandu Sharma
Keywords
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- EP ID EP220066
- DOI 10.14260/Jemds/2017/846
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