Design And Characterisation Of Pulsatile Capsule Device For Flurbiprofen Using Natural Excipients
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
The objective of the present study was to design and characterize pulsatile capsule device for Flurbiprofen using natural excipients. The Flurbiprofen fast disintegrating tablets (FDT) were formulated using superdisintegrants isolated from natural sources. Pulsatile capsules were designed using optimized Flurbiprofen FDT PO4 as core and with different natural materials i.e.,Chitosan, Guar Gum and Plantago Ovata husk as plugging materials in different amounts. Pulsatile capsules remained intact in acid buffer of pH 1.2 for 2 hrs due to enteric coating with hydroxyl propyl methyl cellulose phthalate (HPMCP). In Phosphate buffer of pH 6.8, the enteric coat dissolved. The plug material swelled and ejected out of capsule body, thereby liberating the drug into the alkaline fluid medium. With all the formulations absolutely no drug release was observed in first two hours and negligible drug was released in the third hour. The pulsatile capsules developed with Guar Gum as plugging material showed satisfactory lag time of 285-390 min and percent cumulative drug release (% CDR) of 97.88-98.87% at the end of 6.25 hrs to 7.75 hrs, when compared to Chitosan and Plantago Ovata husk which showed lag time of 180-285 min with % CDR of 98.11-98.49% at the end of 5 hrs to 7.25 hrs and 240-300 min with % CDR of 98.00-98.60% at the end of 5.75 hrs to 7 hrs respectively. The mechanism of drug release from the pulsatile capsule was found to be zero order kinetics. The lag period and the drug release could be efficiently modulated by altering the concentration of plugging material.
Authors and Affiliations
Sarfaraz Md. , Surendra Kumar Sharma,, Hark Bahadur Karkee,, Bhawana Thapa, Mohan Ghorasaini
Keywords
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