Design and characterization of olanzapine transfersomes for percutaneous administration
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 2
Abstract
The aim of this research activity is to formulate Soyalecithin based transfersomal nanoparticles for percutaneous administration of Olanzapine for better management against psychotic diseases. Olanzapine transfersomes were formulated by employing thin film hydration followed by high speed homogenization technique. Drug entrapment efficiency of optimized formulation “F3” was found to be 62.42%. In-vitro diffusion studies of all the formulations revealed that the olanzapine transfersomes followed zero order kinetics, ascertaining Peppas mechanism. Application of Korsmeyer-Peppas equation to the data of the formulations revealed that mechanism of olanzapine transfersomes was governed by predominant Non-Fickian diffusion (0.5>n<0.85). Based on the results, the formulation F3 was considered as the better formulation (% Entrapment efficiency- 62.42%, Zeta Potential -1.3mv, % Drug diffusion 61.31±0.12%) for the effective management of psychotic disorders.
Authors and Affiliations
M. KishoreBabu, R. Sireesha, N. Mounica, K. Divya, M. Hemprasad
Keywords
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