Formulation and evaluation of Escitalopram fast dissolving tablets by direct compression method
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
The present study is an attempt to select the best possible diluent, disintegrant combination to formulate rapidly disintegrating tablets of Escitalopram which disintegrates in matter of seconds in the oral cavity, thereby reducing the time of onset of pharmacological action. In this system direct compression method was used, Mannitol as a diluent, Colloidal Silicon Dioxide as a glidant, Crospovidone used as disintegrant and Aspartame used as sweetener for synergetic effect. The results of the drug – excipient compatibility studies revealed that there was no chemical interaction between the pure drug and excipients. Direct compression method was employed to formulate the tablets, because of its cost effectiveness and due to reduced number of manufacturing steps. Based on mathematical models, it was concluded that formulation FC1, FP1, the regression (r=0.97) value was found to be 0.97 fitted into first order release kinetics. The slope value for Pippa’s model was found to be within 0.45-0.89 hence it is follows non fickens diffusion. Non-Fukien’s diffusion refers to combination of both diffusion and erosion control. Hence based on the formulation development and their results, direct compression method is more suitable for Escitalopram Fast Dissolving Tablet in terms of palatability, physical and chemical properties better with reference product.
Authors and Affiliations
J. Jesudas, D. Jeevan Mani Babu, B. Nagendra Babu
Keywords
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