Design and development of buccoadhesive tablets of verapamil hydrochloride
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Verapamil Hydrochloride is widely used in the management of Hypertension, Angina pectoris and Myocardial infraction. The present investigation concerns the development of Buccoadhesive tablets of Verapamil Hydrochloride which were designed to prolong the buccal residence time after oral administration. Buccal tablets of Verapamil Hydrochloride were formulated using four mucoadhesive polymers namely, Carbopol 934 P, HPMC K15M, Hydroxy ethyl cellulose and Sodium corboxymethylcellulose carried out studies for weight variation, thickness, hardness, content uniformity, swelling index, Bioadhesive strength and in-vitro drug release. Formulation of B6 were formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose provided controlled release of Verapamil Hydrochloride over period of 8 hrs. The cumulative % of drug release of formulation B6 was 98.12%.Formulation of B6 which was formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose was established to be the optimized formulation with optimum bioadhesive strength, swelling index and desired in-vitro drug release.
Authors and Affiliations
Yeduka Anjibabu, Debjit Bhowmik, Praveen Khirwadkar, K. P. Sampath Kumar, Rajnish Kumar Singh
Keywords
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