Design and development of buccoadhesive tablets of verapamil hydrochloride
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Verapamil Hydrochloride is widely used in the management of Hypertension, Angina pectoris and Myocardial infraction. The present investigation concerns the development of Buccoadhesive tablets of Verapamil Hydrochloride which were designed to prolong the buccal residence time after oral administration. Buccal tablets of Verapamil Hydrochloride were formulated using four mucoadhesive polymers namely, Carbopol 934 P, HPMC K15M, Hydroxy ethyl cellulose and Sodium corboxymethylcellulose carried out studies for weight variation, thickness, hardness, content uniformity, swelling index, Bioadhesive strength and in-vitro drug release. Formulation of B6 were formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose provided controlled release of Verapamil Hydrochloride over period of 8 hrs. The cumulative % of drug release of formulation B6 was 98.12%.Formulation of B6 which was formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose was established to be the optimized formulation with optimum bioadhesive strength, swelling index and desired in-vitro drug release.
Authors and Affiliations
Yeduka Anjibabu, Debjit Bhowmik, Praveen Khirwadkar, K. P. Sampath Kumar, Rajnish Kumar Singh
Formulation & evaluation of aripiprazole solid lipid nanoparticles for brain targeting
The objective of this research work was to formulate Aripiprazole solid lipid nanoparticles for brain targeting by surpassing the Blood brain barrier (BBB) and increasing the retention time in the brain for better ther...
Development and validation of new RP-HPLC method for simultaneous estimation of drug Thiocolchicoside and Etodolac in tablet dosage form
A simple, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Thiocolchicoside and Etodolac was developed and validated according to ICH guidelines. The quantifica...
Development and evaluation of Bosentan monohydrate loaded lipid-solid dispersions
In the last decade of the last century, solid lipid dispersions (SLD) have been introduced to the literature as a novel carrier system for cosmetic active ingredients and pharmaceutical drugs. SLD consists of biodegrad...
Method development and validation for the simultaneous estimation of Ofloxacin and Tinidazole in bulk and pharmaceutical dosage form by reverse phase HPLC method
A new, simple, accurate, rapid, precise RP-HPLC method was developed for the simultaneous estimation of ofloxacin and tinidazole in bulk and pharmaceutical dosage form. A good chromatographic separation was achieved wi...
Novel challenges of stem cell therapy in neurodegenerative disorders
Neurodegenerative diseases are characterized by progressive dysfunction, loss & death of neurons. In recent years, neurons and glial cells have been successfully generated from stem cells, by this from stem cell brain...