Design and development of buccoadhesive tablets of verapamil hydrochloride
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Verapamil Hydrochloride is widely used in the management of Hypertension, Angina pectoris and Myocardial infraction. The present investigation concerns the development of Buccoadhesive tablets of Verapamil Hydrochloride which were designed to prolong the buccal residence time after oral administration. Buccal tablets of Verapamil Hydrochloride were formulated using four mucoadhesive polymers namely, Carbopol 934 P, HPMC K15M, Hydroxy ethyl cellulose and Sodium corboxymethylcellulose carried out studies for weight variation, thickness, hardness, content uniformity, swelling index, Bioadhesive strength and in-vitro drug release. Formulation of B6 were formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose provided controlled release of Verapamil Hydrochloride over period of 8 hrs. The cumulative % of drug release of formulation B6 was 98.12%.Formulation of B6 which was formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose was established to be the optimized formulation with optimum bioadhesive strength, swelling index and desired in-vitro drug release.
Authors and Affiliations
Yeduka Anjibabu, Debjit Bhowmik, Praveen Khirwadkar, K. P. Sampath Kumar, Rajnish Kumar Singh
Keywords
Related Articles
- EP ID EP33282
- DOI -
- Views 253
- Downloads 0
FORMULATION AND EVALUATION OF MATRIX FLOATING TABLETS OF OFLOXACIN AND TINIDAZOLE COMBINATION
Floating matrix tablets of Ofloxacin and tinidazole were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Ofloxacin chosen as a choice of drug because it i...
Evaluation of anti-ulcer activity of Clitorea ternatea Leaves (Linn) extract in Wistar rats
The aim of the present study is to evaluate the antiulcer activity of Clitorea ternatea leaves (Linn) in experimentally induced animal models. In this study the leaves of Clitorea ternatea was extracted with petroleum...
Diagnosis and management of common clinical presentations of primary glaucomas
The article discusses the common causes of glaucoma, types of glaucoma, diagnosis and treatment. The article also discusses various equipment and their usage in the diagnosis of glaucoma.
Design and development of buccal tablets of Metoprolol tartarate by core in cup technology
A precise, simple, cost effective, accurate Ultra violet spectrophotometric method has been developed for the determination of Edoxaban Tosylate Monohydrate (EDTM) in the Pharmaceutical dosage form. EDTM shows highest...
Investigation of phytochemicals and anti-diarrhoeal potential of an ignored grassCyperus esculentus L. root
Diarrhoea is a condition that involves the frequent passing of loose or watery stools. According to the WHO, approximately 3.5 million deaths each year are attributable to diarrhoea. Medicinal plants have been used as...