Design and development of Metformin hydrochloride Trilayered sustained release tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
Diabetes is one of the major causes of death and disability in the world. Diabetes results from decreased secretion of insulin, decreased insulin action or both. The main aims of the investigation was to design and development of trilayer floating tablets of metformin hydrochloride and also study the influence of concentrations of HPMCK 100 on various properties of tablet and tri-layer tablets were formulated by wet granulation method. Drug - excipient compatibility studies were conducted by FTIR spectroscopy. The prepared granules, tablets were evaluated. In-vitro release data revealed that F5 formulation sustained the release for 12 hours and the release data was fitted into zero order, first order, Higuchi and Peppas equations. The drug release from the formulation followed zero kinetics and exhibits Peppas mechanism. Release exponents ‘n’ was found less than 0.85 indicating the release governed by non-fickian anomalous transport mechanism.
Authors and Affiliations
Venkateswara Rao T, Bhadramma N, Raghukiran CVS, Madubabu K
Keywords
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