Design and development of Metformin hydrochloride Trilayered sustained release tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
Diabetes is one of the major causes of death and disability in the world. Diabetes results from decreased secretion of insulin, decreased insulin action or both. The main aims of the investigation was to design and development of trilayer floating tablets of metformin hydrochloride and also study the influence of concentrations of HPMCK 100 on various properties of tablet and tri-layer tablets were formulated by wet granulation method. Drug - excipient compatibility studies were conducted by FTIR spectroscopy. The prepared granules, tablets were evaluated. In-vitro release data revealed that F5 formulation sustained the release for 12 hours and the release data was fitted into zero order, first order, Higuchi and Peppas equations. The drug release from the formulation followed zero kinetics and exhibits Peppas mechanism. Release exponents ‘n’ was found less than 0.85 indicating the release governed by non-fickian anomalous transport mechanism.
Authors and Affiliations
Venkateswara Rao T, Bhadramma N, Raghukiran CVS, Madubabu K
Keywords
Related Articles
- EP ID EP33149
- DOI -
- Views 280
- Downloads 0
Protective role of methanolic extract of Polygonum glabrum willd against Cisplatin and Gentamycin induced nephrotoxicity in Albino rats
The nephroprotectic effect of Methanolic extract of Polygonum glabrum willd was studied in Cisplatin,Gentamycin induced Albino Rats. Oral administration of extract to albino rats [200mg/kg and 400mg/kg for 14, 8 days]...
Potential Impact of Nanomaterials in Information and Communication Technologies
Nanomaterials are throwing the doors open to a hyper-tech era in which electronics and information and communication technology (ICT) are going to become ubiquitous. Enormous progress has been made by making a transiti...
Formulation and evaluation of sustained release tablets of Zidovudine by using hibiscus as a natural polymer
The present work is aimed at preparing and evaluating Sustained-release (SR) matrix tablets of Zidovudine tablet using different polymers. Systematic studies were conducted using different concentration of rate releasi...
Amlodipine: the upcoming threat to Periodontist
Gingival hyperplasia is one of the side effects commonly caused by three major groups of drugs such as a) anticonvulsants b) antihypertensives – calcium channel blockers c) immunosuppressants. Previously among antihype...
Invitro anti-arthritic, anti-inflammatory and anti-oxidant activity of Cissus quadrangularis linn
The present investigation deals with the study of in vitro anti-arthritic activity by inhibition of protein denaturation method, anti- inflammatory by HRBC membrane stabilization method and anti-oxidant activity by DPP...