DESIGN AND DEVELOPMENT OF pH-TRIGGERED IN SITU GELLING SYSTEM OF CIPROFLOXACIN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The aim of the present work was formulation and evaluation of in situ gelling system of ciprofloxacin. The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the cul-de-sac. Hence, the purpose of the present work was to formulate pH-triggered, temperature triggered & ion activated in situ Gelling system of ciprofloxacin to provide sustained release of drug based on polymeric carriers that undergo sol-to-gel transition upon change in pH. The ciprofloxacin in situ gelling system formulated by using poly acrylic acid (Carbopol 934) in combination with hydroxyl propylmethyl cellulose (HPMC) which acted as viscosity enhancing agent. The developed formulation was efficacious, stable, non-irritant and provided sustained release over 8-hour period and it is a viable alternative to conventional eye drops by virtue of its ability to enhance bioavailability through its longer precorneal residence time & ability to produced sustained drug release.
Authors and Affiliations
Umesh Lokhande , Vikas Gorde , M. V. Gadhave , S. L. Jadhav , D. D. Gaikwad
Keywords
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