Design and Development of Ramipril Transdermal Patch For Treating Hypertension
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 2
Abstract
A good Transdermal patch containing can be formulated by solvent casting technique using as film former and propylene glycol as plasticizer such Transdermal patches are advantages in providing effective treatment for Hypertension with enhanced patient compliance. From the invitro release results observed that the films prepared by using different ratios of HPMCK 15M, PVPK30 and EC Transdermal Ramipril patches were formulated using DBP as a plasticizer and DMSO as a penetration enhancer proved to exhibit better release characteristics. It can be reasonably concluded that Ramipril can be formulated into Transdermal patches to prolong its release characteristics. Thus the formulation HPMCK15M and Ethyl Cellulose was found to be the best for controlled release. The Cumulative drug release from Formulation R10 was found to be 99.64% after 24 hrs. So the formulation R10 is emerged as ideal formulation for Ramipril because it showed better release with sustained effect as compared to other formulations.
Authors and Affiliations
K. P. Sampath Kumar, Debjit Bhowmik, Rishab Bhanot
Keywords
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