PREPARATION, CHARACTERIZATION AND EVALUATION OF OLMESARTAN MEDOXOMIL-Β CYCLODEXTRIN COMPLEXES
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
Olmesartan medoxomil is a poor water soluble drug. There are numerous approaches available and reported in literature to enhance the solubility of poor water soluble drugs among which cyclodextrin complexation is predominant. β-cyclodextrin was used since this possess a special ability to complex with drugs enabling them to increase solubility, reduce bitterness, enhance stability and decrease tissue irritation upon dosing. Olmesartan medoxomil-β cyclodextrin complexes were prepared and characterized by FT-IR and SEM, studies. The results showed the formation of true inclusion complexes at molar ratio 1:5. In contrast crystalline drug was detectable in all other products. The dissolution of Olmesartan medoxomil from all the prepared complexes has been carried out to determine the most appropriate ratio that can be used for further development like tablet formulation for oral delivery. The complexes prepared by physical mixture method in 1:5 ratio showed superior dissolution profile when compared to complexes prepared in other ratios. From this research work it can be concluded that β CD has potential to increase the solubility of Olmesartan medoxomil and true complexes are formed in 1:5 ratio and because of the higher dissolution profile it can be used for further formulations.
Authors and Affiliations
V. Prudhvi Raj, Subhashis Debnath, T. Malleswari, B. Bhaskar Naik, M. Niranjan Babu
Keywords
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