Formulation development and evaluation of immediate release tablets of Rasagiline Mesylate
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 1
Abstract
The aim of this investigation was to develop and evaluate immediate release drug delivery system for Rasagiline Mesylate and comparing with marketed product. Immediate released based tablets formulated using different concentrations of different grades of Mannitol, Polyvinyl pyrrolidine, Croscarmellose sodium, sodium starch glycolate, cros povidone, talc, magnesium sterate were used to develop nine formulations (F1 – F9) using direct compression & wet granulation methods and were subjected to physicochemical and in vitro dissolution studies by comparing with marketed product. The net content of Rasagiline Mesylate was 1.56mg and the total tablet weight was 100mg. Excipients used in the formulation reduces the cost, which are available at lower price in market. As the excipients used are mostly available and cheaper at cost. The study includes development of the robust and stable product, which complies with the marketed product.
Authors and Affiliations
A. Madhusudhan Reddy, P. SrinivasaBabu, O. Venu, J. Sindhura, D. Navya sri, B. Nagalakshmi
Keywords
Related Articles
- EP ID EP33364
- DOI -
- Views 268
- Downloads 0
MICROEMULSIFYING DRUG DELIVERY SYSTEM-NEW ERA OF DRUG DELIVERY SYSTEM
Micro emulsions are isotropic, thermodynamically stable transparent system of oil, water and surfactant, frequently in combination with a co-surfactant. These versatile systems are currently of great technological and...
FORMULATION AND EVALUATION OF MATRIX FLOATING TABLETS OF OFLOXACIN AND TINIDAZOLE COMBINATION
Floating matrix tablets of Ofloxacin and tinidazole were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Ofloxacin chosen as a choice of drug because it i...
Hypoglycemic and antihyperglycemic activities of Bauhinia thonningii (caesalpiniaceae) fruit in rat wistar
Diabetes is a metabolic disease characterized by chronic hyperglycemia resulting from a defect in the secretion of insulin and / or the action of this hormone. The therapeutic management of this pathology in most devel...
Formulation and evaluation of Diclofenac potassium transdermal patches for enhanced therapeutic efficacy
Today 74% of the drugs are taken orally and are found not to be safe or effective as desired because they produce wide ranging fluctuation in drug concentration in blood stream. Continuous I.V infusion is recognized as...
Synthesis and pharmacological evaluation of 5-substituted-2,4-thiazolidinedione
The aim of present study is to synthesize a set of 5-substituted-2,4-thiazolidinediones as antimicrobial. These compounds were evaluated for their antimicrobial activity. The structures of the new derivatives were esta...