Evaluation of anti-ulcer activity of Clitorea ternatea Leaves (Linn) extract in Wistar rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
The aim of the present study is to evaluate the antiulcer activity of Clitorea ternatea leaves (Linn) in experimentally induced animal models. In this study the leaves of Clitorea ternatea was extracted with petroleum ether, chroloform and ethanol. The preliminary phytochemical screening was also undertaken and it revealed that the plant extracts have alkaloids, tannins, flavonoids, glycosides and steroids. Chloroform and Ethenolic extracts of Clitorea ternatea (Linn.) were investigated for gastric protective activity on pylorus ligation induced ulcer and ethanol induced ulcer models. A number of biochemical parameters such as gastric volume, pH of gastric content, ulcer index, free acidity and total acidity, dissolved mucous substances such as total protein, mucin were estimated and the extracts at a concentration of 250 mg/kg produced a protective effect on ulcer‐induced models when compared with the standard drug Omeprazole (20mg/kg, p.o.). Some of the antioxidant enzymes levels (glutathione, superoxide dismutase and catalase) were also determined. The result of present study revealed that ethanolic extract of Clitorea ternatea was more potent than the ethanolic extract when compared with the standard. From the results it can be concluded that the plant have potent antiulcer activity that may be due to the presence of flavonoids, tannins or antioxidants.
Authors and Affiliations
Dwivedi Vivek, Chander B. Semwal , Narayan H Yadav
Keywords
Related Articles
- EP ID EP33206
- DOI -
- Views 347
- Downloads 0
Comparison of efficacy and adverse effect of Gliclazide, Metformin and Glipizide, Metformin combinations on type 2 diabetes patients
The aim of the present study was to compare the effect of Gliclazide+Metformin and Glipizide+Metformin Combinations on Type 2 Diabetes Patients. The percentage reduction in FPG and PPG in Gliclazide Metformin combinati...
A COMPREHENSIVE REVIEW OF ELADI VATI
Herbal medicines are the synthesis of therapeutic experiences of generations of practising physicians of indigenous systems of medicine for over hundreds of years while nutraceuticals are nutritionally or medicinally e...
Sustained release drug delivery system: review
Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. The basic rationale of sustained relea...
Highly selective, sensitive and precise Bioanalytical method for the estimation of amoxicillin and clavulanic acid in nano gram range in Albino rat's plasma
LC-MS/MS method for the determination of amoxicillin and clavulanic acid in Albino rat's plasma was developed and validated according to currently accepted FDA guidelines of Bioanalytical method validation. The retenti...
Fabrication, Characterisation and Evaluation of Rivastigmine Loaded Transdermal Films for the Patients Enduring with Alzheimer’s disease
Alzheimer’s disease is the most common type of dementia which makes up 50 – 70% cases. Various cholinesterase inhibitors are used to treat conditions related to dementia. Among many drugs Rivastigmine is most promising...