Fabrication and evaluation of oro-gel containing ferrous fumarate
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
The present study aimed to develop Ferrous Fumarate oral jellies for the treatment of iron deficiency anemia. These jellies were prepared by using Carbapol 940 or tragacanth with different concentrations as a gelling agent. The benefits of these prepared jellies are increased bioavailability by-passing first pass metabolism. Difficulty in swallowing (dysphagia) is common among all groups, especially in elderly and pediatrics. The persons suffering from dysphagia may get choked when they consume liquid formulations, thus to alleviate such problem liquid formulations of high viscosity were prepared. Various parameters like appearance, viscosity, pH, spreadibility, syneresis and drug content were performed and all were shown satisfactory results. The in-vitro dissolution test was performed in 1% SLS using USP apparatus type II (paddle), at 75 rpm. The formulations with Tragacanth10% (F8) and Carbapol 940 (10%) (F10) were selected for further stability studies because these formulations shows better results in all the parameters.
Authors and Affiliations
N. Narasimharao, P. srinivasababu, S. Sumantha, E. Amala, P. N. Abhishekvarma, N. Ayesha, B. Rohini, N. Bharath
Keywords
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