Abstract

Present research work was aimed at design and evaluation of fast dissolving tablets of domperidone using super disintegrant like cross povidone ,cross carmellose sodium, sodium starch glycolate and indion 414 with various concentration of 2.5%.5% and 7.5%by direct compression method. ATR spectra shown that there are no polymer and drug interactions. The prepared tablets were evaluated for various post compression parameters like hardness, weight variation, friability, content uniformity, wetting time and water absorption ratio. The values of all parameter were within pharmacopoeial limits .Among all the formulations F12 (7.5% of indion 414) as shown 10 seconds disintegration time. In vitro drug release studies shows that 100.1% drug release within 20 minutes, Hence this formulation was considered as the best formulation, and its Short term stability studies were conducted at 40±2°/75%±5% RH up to 3 months it was found that in vitro disintegration time and drug release were not changed during stability studies.

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