Abstract

The goal in designing sustained release drug delivery system is to reduce the frequency of the dosing, reducing the dose & providing uniform drug delivery. Sustained release dosage forms provide better control of plasma drug levels, less dosage frequency, less side effect, increased efficacy and constant delivery. The Aim of the study is related to the formulation and evaluation of Ofloxacin 25ml of microencapsulated suspension by solvent evaporation method. The Preparation contains six formulations of suspensions with 2 different polymers with different concentrations as Ofloxacin resinate + HPMC, Ofloxacin resinate + Carbopol 934. The prepared batches of Ofloxacin microencapsulated suspension were evaluated for the pH, viscosity, sedimentation volume; density, drug content and antibacterial activity of all the six formulations were performed. Formulations F-3, F-6 gave better sustained release and antibacterial activity. Comparitive study of F-3, F-6 with marketed product reveal the F-3 is best fitted formulation for preparation of microencapsulated suspension.

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