Abstract

Inherited disease of secretary glands is known as Cystic fibrosis (CF). Cystic fibrosis mostly affects the pancreas, lungs, liver, intestines and sex organs. Like it affects other vital organs it doesn't affect the brain. The main causes of cystic fibrosis are defect in the CFTR gene. The CFTR gene makes a protein that controls the movement of salt and water in and out of body's cells. Every person inherits two CFTR genes one from each parent. Persons who receive or inherit a faulty gene from each parent will have cystic fibrosis. Diagnosis of cystic fibrosis is based on the results from various tests sweat test, newborn screening, cystic fibrosis carrier testing, prenatal screening and other tests. In treatment of cystic fibrosis exercise therapy, chest physical therapy and medicines are used. In medicinal therapy mostly antibiotics, anti-inflammatives, mucolytics, antihistamines, vitamins, drugs acting on GI track, stool softeners, bronchodilators, and pancreatic enzymes are used. Oxygen therapy and lung transplant are the advance treatments for lung diseases. As new treatments are developed for patients with cystic fibrosis, efforts should be made to balance treatment burden with quality of life. This review highlights emerging treatments, obstacles to optimizing outcomes, and key future direction for research on cystic fibrosis and its treatment

Authors and Affiliations